Registration Dossier
Registration Dossier
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EC number: 247-279-7 | CAS number: 25811-35-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on freshwater fish up to the limit of water solubility. Read across.
Key value for chemical safety assessment
Additional information
Data on the short-term toxicity of
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) to fish are not available. Therefore in accordance to
Regulation (EC) No 1907/2006 Annex XI, 1.5, a read across to the
structurally related substance pentaerythritol tetraesters of
n-decanoic, n-heptanoic, n-octanoic and n-valeric acids (CAS 68424-31-7)
was conducted. This read-across is justified in detail in the overall
summary (IUCLID section 6.1) and within the analogue justification in
IUCLID Section 13.
The short toxicity of the read-across substance was investigated in a
semi-static study equivalent or similar to OECD 203 (Combert and
Caunter, 1991). The fish (Salmo gairdneri) were exposed to the substance
for 96 hours. At test termination a LC50 (96h) > 1000 mg/L (nominal) was
determined. No mortality was observed within the tested concentration
(1000 mg/L nominal) during 96h exposure. As the test material did not
dissolved completely in the dilution water, the tested concentration
demonstrated a worst case. Thus, toxic effects were not observed within
the range of the water solubility (< 1 mg/L). Based on the available
result from a structurally related read-across substance (in accordance
to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by
a similar ecotoxicological profile and comparable structure, it can be
concluded that 2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl
bisheptanoate (CAS 25811-35-2) will not exhibit short-term effects on
fish up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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