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EC number: 247-825-4 | CAS number: 26586-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
IN VITRO
In a reverse gene mutation assay in bacteria (BASF, 1992), strains TA 1535, TA 1537, TA 98 and TA 100 of S. typhimurium were exposed to C5 acetate (purity 98.8%; solvent: DMSO) at concentrations of up to 5000 µg/plate in the presence and absence of mammalian metabolic activation (Standard Plate test: 4-5000 µg/plate; Preincubation Test: 4-1000 µg/plate; Liquid suspension Assay: 4-1250 µg/plate).
C5 acetate was tested up to cytotoxic concentrations. There was no evidence of mutagenicity in any tester strain in the Standard Plate test with and without metabolic activation; in any tester strain in the Preincubation Test with and without metabolic activation; in any tester strain in the Liquid Suspension Assay with metabolic activation; and in tester strains TA 1535 and TA1537 in the Liquid Suspension Assay without metabolic activation. Controversial results were observed in the Liquid Suspension Assay without metabolic activation for TA 98 (slightly enhanced figures at 500 - 1000 µg/plate; factor 1.8-2.0; this could not be confirmed by a second experiment). Positive reaction was observed in the Liquid Suspension Assay without metabolic activation for TA100 from about 250 µg/plate (factor 1.8) onward with an increase in the number of mutant colonies by a factor of 8.1 at 1250 µg/plate. The positive controls induced the appropriate responses in the corresponding strains. Overall, there was no evidence of induced mutant colonies over background.
This study is classified as acceptable. This study satisfies the requirement for Test Guideline OECD 471 for in vitro mutagenicity (bacterial reverse gene mutation) data.
IN VIVO
No data.
Short description of key information:
IN VITRO
Not mutagenic in bacteria:
- not mutagenic in the standard Ames Test (Standard Palte Test and Preincubation Test)
- mutagenic in a modified Ames Test (Liquid Suspension Assay).
IN VIVO
No data are available.
Endpoint Conclusion:
Justification for classification or non-classification
There is no need to classify C5 acetate for mutagenicity according to the Directive 67/548/EC or GHS criteria.
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