Registration Dossier
Registration Dossier
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EC number: 248-882-8 | CAS number: 28173-59-3
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 May 2018 - 18 May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: not specified
- Specific details on test material used for the study:
- Batch: 20140120-2 (China)
Purity: 91.3 % w/w (total organic constituents) - Radiolabelling:
- no
- Test temperature:
- 30 °C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Agilent Technologies 1100 Series
- Type, material and dimension of analytical (guard) column: XSelect HSS Cyano 5 µm (150 x 4.6 mm id)
- Detection system: variable wavelength (VW)
MOBILE PHASES
- Type: Methanol: purified water (55:45 v/v)
- Experiments with additives carried out on separate columns: no
- pH: 5.6
- Solutes for dissolving test and reference substances: Acetonitrile
DETERMINATION OF DEAD TIME
- Method: The dead time was determined by measuring the retention time of formamide (purity 99.6 %) of a 757 mg/L solution in methanol: purified water (50:50 v/v).
REFERENCE SUBSTANCES
- Identity: Acetanilide, Phenol, Atrazine, Triadimenol, Linuron, Naphthalene, Endosulfan-diol, Fenthion, a-Endosulfan, Phenanthrene, Diclofop-methyl, DDT
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10 µL
- Quantity of reference substances: 10 µL
- Intervals of calibration: not specified
REPETITIONS
- Number of determinations: 2
- Key result
- Type:
- log Koc
- Value:
- > 5.63 dimensionless
- pH:
- 7
- Temp.:
- 30 °C
- Matrix:
- none
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: see table 1
- Details of fitted regression line (log k' vs. log Koc): See attachment
- Graph of regression line attached: Yes
- Average retention data for test substance: See table 2 - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test item has been determined to be greater than 4.3 x 10e5, log10 Koc >5.63. The results classify the test item as immobile.
- Executive summary:
Adsorption Coefficient was found to be greater than 4.3 x 10E5, log10 Koc >5.63, using the HPLC screening method, designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The results classify the test item as immobile.
Reference
Table 1.
Standard | Retention Time (min) | Mean Retention Time (min) | Capacity Factor (k') | Log10 k' | Log10 Koc | |
Injection 1 | Injection 2 | |||||
Acetanilide | 2.609 | 2.609 | 2.609 | 0.349 | -0.457 | 1.25 |
Phenol | 2.483 | 2.483 | 2.483 | 0.284 | -0.547 | 1.32 |
Atrazine | 3.571 | 3.571 | 3.571 | 0.847 | -0.0723 | 1.81 |
Triadimenol | 4.995 | 5.000 | 4.998 | 1.584 | 0.200 | 2.40 |
Linuron | 5.078 | 5.078 | 5.078 | 1.626 | 0.211 | 2.59 |
Naphthalene | 4.436 | 4.436 | 4.436 | 1.294 | 0.112 | 2.75 |
Endosulfan-diol | 6.137 | 6.137 | 6.137 | 2.173 | 0.337 | 3.02 |
Fenthion | 7.376 | 7.366 | 7.371 | 2.812 | 0.449 | 3.31 |
a-Endosulfan | 10.175 | 10.175 | 10.175 | 4.261 | 0.630 | 4.09 |
Diclofop-methyl | 11.054 | 11.074 | 11.064 | 4.721 | 0.674 | 4.20 |
Phenanthrene | 8.022 | 8.003 | 8.013 | 3.143 | 0.497 | 4.09 |
DDT | 21.142 | 21.088 | 21.115 | 9.918 | 0.996 | 5.63 |
Table 2.
Injection | Retention Time (min) | Capacity Factor (k') | Log10 k' | Log10 Koc |
1 | 31.482 | >9.92 | >0.996 | >5.63 |
2 | 31.492 | >9.92 | >0.996 | >5.63 |
Description of key information
Adsorption Coefficient was found to be greater than 4.3 x 10E5, log10 Koc >5.63
Key value for chemical safety assessment
- Koc at 20 °C:
- 43 000
Additional information
Adsorption Coefficient was found to be greater than 4.3 x 10E5, log10 Koc >5.63, using the HPLC screening method, designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The results classify the test item as immobile.
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