Registration Dossier
Registration Dossier
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EC number: 253-523-3 | CAS number: 37482-11-4
Carcinogenicity
Administrative data
Description of key information
No specific carcinogenicity data are available on sodium 2-mercaptoethanolate, however, its simple chemical structure with no structural alerts for likely genotoxic carcinogenic activity, together with the conclusion that sodium 2-mercaptoethanolate is not genotoxic, provide a strong case for concluding that it not will show any significant carcinogenic activity.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In accordance with section 1 of REACH Annex XI, testing does not appear to be scientifically necessary since negative genotoxicity data and consideration of its simple chemical structure provide sufficient weight of evidence to conclude sodium 2-mercaptoethanolate is unlikely to show any significant carcinogenic activity. Therefore, the substance is not classified for carcinogenicity according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Additional information
There are no carcinogenicity studies available for sodium 2 -mercaptoethanolate. However, a consideration of its simple chemical structure, which carries no alerts for likely genotoxic carcinogenic activity from established Structure Activity Relationship analysis (Ashby and Tennant, 1988), together with the conclusion that sodium 2-mercaptoethanolate is not genotoxic, provide a strong case for concluding that it will not show any significant carcinogenic activity. Taking this information into account, it is considered that there is no justification for conducting further animal carcinogenicity studies. The above reasoning leads to the conclusion that sodium 2-mercaptoethanolate can be considered to have low concern for human carcinogenicity.
References:
Ashby J and Tennant RW (1988) Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP. Mutat Res 204: 17-115.
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