Registration Dossier
Registration Dossier
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EC number: 257-077-0 | CAS number: 51240-95-0
Endpoint summary
Administrative data
Description of key information
The test substance was tested in the rabbit primary skin irritation/corrosion test to determine its possible irritating or corrosive properties.
The flank skin of 3 female rabbits was exposed to 0.5 ml of the test substance for 4 hours using semi-occlusive dressing. This resulted in very slight, temporary oedema, and moderate erythema, which persisted for seven days in one animal and for two to three days in the other animals. The treated skin area of all animals showed scale formation from day 7 onwards. The mean values for eshar/erythema is =>1.5 and =< 2.3 for 2 out of 3 animals. The oedema score is < 1.5. Although the scoring does not warrant C&L the substance is classified as irritant because of the scaling observed from day 7 onwards.
The substance was tested, in the rabbit acute eye irritation/corrosion test to determine its possible irritating or corrosive effects. Instillation of 0.1 ml of the test substance in one of the eyes of three female rabbits resulted in slight redness and swelling of the conjunctivae. In two of the animals the conjunctival effects disappeared within twenty-four hours, whereas in one animal slight redness persisted for forty-eight hours. No adverse effects on the cornea and the iris were observed in any of the rabbits during the entire observation period.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The registered substance, ±70% in phlegmatizer, is a skin irritant; it is not irritating to the eye.
Justification for selection of skin irritation / corrosion endpoint:
K1: The study was performed according to OECD guidelines and GLP.
Justification for selection of eye irritation endpoint:
K1: The study was performed according to OECD guidelines and GLP.
Justification for classification or non-classification
Based on the results of in vivo skin and eye irritation studies in rabbits, the substance is classified as a cat. 2 skin irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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