Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In Magnusson and Kligman Guinea-Pig Maximization test (OECD TG 406), C11-C14, n-alkanes (<2% aromatics) and C10-C13, n-alkanes (<2% aromatics) were not dermal sensitizers . Moreover, in studies on human volunteers using C5-C20, n-alkanes (<2% aromatics), there were no signs of irritation or sensitization effects of the test substances (IUCLID section 7.10.4). Consequently, Paraffins (petroleum), normal C>10, is not skin sensitisating.


Migrated from Short description of key information:
As C11-C14, n-alkanes (<2% aromatics) and C10-C13, n-alkanes (<2% aromatics) were not dermal sensitizers using a Magnusson and Kligman Guinea-Pig Maximization test (OECD TG 406), Paraffins (petroleum), normal C>10 is also not expected to cause skin sensitisation.

Respiratory sensitisation

Endpoint conclusion
Additional information:

There are no reports of respiratory sensitization from the categories C9 -14 aliphatics (<2 % aromatics) and C14 -C20 aliphatics (<2% aromatics) in laboratory animals or humans. However, skin sensitization studies utilizing these two categories found no indication of skin sensitization in guinea pigs. Additional studies on C14-C20 aliphatics (<2% aromatics) in humans also found no indication of skin sensitization. With these observations, it is presumed that the two categories C9 -C14 aliphatics and C14 -C20 aliphatics as for C10 -C17, (<2% aromatics) will not be a respiratory sensitizing agents.

Justification for classification or non-classification

These findings do not warrant the classification of C10 -17, n-alkanes (<2 % aromatics) hydrocarbon solvents as a skin or respiratory sensitizer under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.