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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The test substance showed no to slight sensitizing effects in an LLNA with SI<3. Therefore, according to GHS criteria, DADTDG is not classified.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline Study, GLP with certificate
Qualifier:
according to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Qualifier:
according to guideline
Guideline:
EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
yes (incl. QA statement)
Type of study:
mouse local lymph node assay (LLNA)
Species:
mouse
Strain:
CBA
Sex:
female
Details on test animals and environmental conditions:
Source:
Age 8-12 weeks (beginning of acclimatisation)
weight 18.6 - 21.5 (beginning of acclimatisation)
3 Test groups/4 animals
1 control group

Husbandry:
Standard laboratory conditions 22+-3°C, 30-70% rel. humidity, 10-15 air changes/h
12/12 light/dark 8 hour music during light period
in groups with four macrolon type 3 cages with lignocell soft bedding

Diet: Std Kiba 3422 lot# 84/02 mouse maintenance diet ad libitum, community water (Itingen) ad libitum
Vehicle:
other: ethanol:water 2:3 v/v
Concentration:
25% , 50% and 100% undiluted
No. of animals per dose:
4
Positive control substance(s):
hexyl cinnamic aldehyde (CAS No 101-86-0)
Positive control results:
Sensitivity and reliability of the test was assessed by use of alpha-hexylcinammaldehyd which is known for a positive reaction in CBA mice. Study RCC no. 846871 was performed betwenn Jan. 8th to Jan. 22nd, 2003.
Parameter:
SI
Value:
1.2
Test group / Remarks:
test material concentration: 48%
number of lymphnodes: 8
Parameter:
SI
Value:
1.2
Test group / Remarks:
test material concentration: 12.5%
number of lymphnodes: 8
Parameter:
SI
Value:
1
Test group / Remarks:
test material concentration: 24%
number of lymphnodes: 8
Conclusions:
In this study stimulation indices (S.I.) of 1.0 to 1.2 were determined for the test material concentrations of 25, 50 and 100% w/v in ethanol/water 2:3 by volume.
The test material diammonium dithiodiglycolate 48% was found to be a non sensitizer (S.I. <3) when tested at concentrations up to 100% (undiluted).
Diammonium dithiodiglycolate 48% w/w causes slight to moderate skin irritation at concetration of 100% on the dorsum of the ear lobes in mice.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
Migrated from Short description of key information:
LLNA: not sensitizing

Justification for selection of skin sensitisation endpoint:
GLP and OECD TG study

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available data, the substance is not classified.