Registration Dossier
Registration Dossier
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EC number: 270-877-4 | CAS number: 68479-98-1
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.13 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 9
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 45
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
DMELs were not calculated. The weight-of-the-evidence from the genotoxicity and carcinogenicity studies support that DETDA is not genotoxic and not a carcinogen at doses that do not cause excessive toxicity.
REFERENCES
ECHA (2008) Guidance on information requirements and chemical safety assessment, Chapter R.8: Charactersation of dose [concentration]-response for human health, European CHemicals Agency (ECHA), GUIDEANCE FOR THE IMPLEMENTATION OF REACH, pp. 1 -150.
ECETOC (2003) Derivation of assessment factors for human health risk assessment, European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), TECHNICAL REPORT NO. 86, pp. 1-86.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.1 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 50
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 12
- Modified dose descriptor starting point:
- BMDL10
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
REFERENCES
ECHA (2008) Guidance on information requirements and chemical safety assessment, Chapter R.8: Charactersation of dose [concentration]-response for human health, European CHemicals Agency (ECHA), GUIDEANCE FOR THE IMPLEMENTATION OF REACH, pp. 1 -150.
ECETOC (2003) Derivation of assessment factors for human health risk assessment, European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), TECHNICAL REPORT NO. 86, pp. 1-86.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
