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Diss Factsheets
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EC number: 271-968-1 | CAS number: 68647-71-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
A toxicokinetic assessment was performed based on the available physico-chemical data and available toxicological information.
Introduction
The substance is a UVCB organic substance. No experimental studies on the absorption, metabolism, distribution, or elimination of Tall oil, potassium salt in mammals are available. However, information is available from existing toxicology studies on the compound, or for other very similar materials, and this data is used to infer, where possible, the potential toxicokinetic properties of the compound.
Physicochemical properties
Systemic availability of the substance depends on its ability to be absorbed across body surfaces. Factors that affect this process include water solubility, lipophilicity (measured by the partition coefficient, Kow) and molecular size. Given the large number of components within the compound, and excluding the potassium, it has a molecular weight of ca. 250-350 g/mol. It is considered soluble in water (visually determined as 93.8 g/L in purified water at 20 ºC). The log Kow ranged from 5.64 to 7.22, with a weight average log10 Kow calculated to be 6.4 (measured at 40 ºC).
Absorption
Oral absorption
The acute oral LD50 of the read across compound (crude tall oil, EC no. 931-433-1) was greater than 2000 mg/kg bw. In addition, no gross abnormalities were observed at necropsy. In a OECD 422 repeat-dose/reproductive toxicity screening study with distilled tall oil (EC 232 -304 -6), effects on liver function were seen at high doses (500 mg/kg bw/day). This finding suggests that oral absorption of distilled tall oil takes place up to some extent. In the absence of quantitative information, 50% bioavailability following oral administration is assumed for the purposes of human risk assessment.
Dermal absorption
Acute dermal toxicity studies were conducted with the read-across substance crude tall oil, but no adverse effects were observed in this study. Skin irritation and skin sensitisation studies with crude tall oil produced no signs that the test substance reacted chemically with the skin. According to the ECHA guidance, substances with MW less than 100 are expected to cross this skin barrier fairly easily. For substances with MW greater than 500 are difficult to get absorbed. For the purposes of risk assessment however, 50% bioavailability is assumed following dermal absorption.
Inhalation absorption
In the absence of any quantitative data, absorption of the compound is considered to be 100%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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