Disodium 6-amino-5-[[4-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4-hydroxynaphthalene-2-sulphonate

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

03/09/2014 to 10/09/2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient)

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: SBL/027/LRB

Analytical method:

high-performance liquid chromatography

Type:

log Pow

Partition coefficient:

< -3.56

Temp.:

20 °C

Remarks on result:

other: pH is not available

Details on results:

Pow : 0.000271

Calculation of the partition coefficient log Pow from the preliminary tests

The partition coefficient P ow may be estimated from the saturation concentrations in n-octanol and water by the following equation:

P _ow = cs octanol /cs water

s= saturation

With the data obtained from the experiments in preliminary visual estimation of the n-octanol solubility (cs < 20 mg/l) and in the preliminary test (water solubility: cs = 12.9 g/l) the partition coefficient was calculated as log P_OW < -2.8

Due to the fact, that the n-octanol solubility is below the LoQ, the partition coefficient n-octanol/water has to be estimated from the individual solubilities in water and n-octanol.

Calculation of the partition coefficient log Pow from the individual solubility in water and n-octanol

By means of the flask method, the saturation concentration of the test item in n-octanol was determined to: <3.5 mg/l.

By means of the flask method, the saturation concentration of the test item in water was determined to: 12.9 g/l

Conclusions:

The partition coefficent n-octanol/water (log Pow) of FAT 40062/C was determined to <-3.56.

Executive summary:

The partition coefficent n-octanol/water of FAT 40062/C was carried out according to OECD guideline 107 and EU method A.8 using flask method. With the data obtained from the experiments in preliminary visual estimation of the n-octanol solubility (cs < 20 mg/l) and in the preliminary test (water solubility: cs = 12.9 g/l) the partition coefficient was calculated as log P_OW<-2.8. In conclusion, based on the study results, the partition coefficent n-octanol/water of the test item at 20°C, from the individual solubilities in water and n-octanol, was determined to log Pow = <-3.56.

Description of key information

The partition coefficent n-octanol/water of FAT 40062/C was carried out according to OECD guideline 107 and EU method A.8 using flask method. With the data obtained from the experiments in preliminary visual estimation of the n-octanol solubility (cs < 20 mg/l) and in the preliminary test (water solubility: cs = 12.9 g/l) the partition coefficient was calculated as log P_OW< -2.8. In conclusion, based on the study results, the partition coefficent n-octanol/water of the test item at 20°C, from the individual solubilities in water and n-octanol, was determined to log Pow = < -3.56.

Key value for chemical safety assessment

Log Kow (Log Pow):

-3.56

at the temperature of:

20 °C