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Diss Factsheets
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EC number: 281-866-9 | CAS number: 84045-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- None
- Qualifier:
- according to guideline
- Guideline:
- other: Internal method " Method A-11, Acute Fish Toxicity"
- Version / remarks:
- Equivalent to OECD Guideline 203
- Deviations:
- no
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Specific details on test material used for the study:
- FAT 40147/E
- Analytical monitoring:
- no
- Details on sampling:
- None
- Vehicle:
- not specified
- Details on test solutions:
- None
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Zebra fish
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- None
- Test temperature:
- 23 °C
- pH:
- 8
- Dissolved oxygen:
- 7.6 - 7.7 mg/L
- Salinity:
- None
- Conductivity:
- None
- Nominal and measured concentrations:
- 300 and 1000 mg/L
- Details on test conditions:
- - No of fish tested for each concentration: 10 each
Refer " Any other information on material and methods incl. tables" for details - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 620 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No mortality was observed with the concentration 300 mg/L throughout the observation period. However, 10 out of 10 fish were found to be dead at the 96 hour observation.
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Sublethal observations / clinical signs:
None
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 was determined to be 620 mg/L.
- Executive summary:
- The acute fish toxicity of FAT 40147/E was assessed in a study conducted according to the internal Ciba method "Method A-11, Acute Fish toxicity", which is equivalent to OECD Guideline 203. Two groups of 10 zebra fish each, were exposed to test concentrations of 300 and 1000 mg/L for 96 hours. No mortality was observed with the concentration 300 mg/L throughout the observation period. However, 10 out of 10 fish were found to be dead with the concentration 1000 mg/L at the 96 hour observation. Hence, the LC50 was determined to be 620 mg/L.
Reference
Description of key information
FAT 40147 was determined to have a 96 hour LC50 value of 620 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 620 mg/L
Additional information
The short term toxicity potential of the substance to fish was assessed using four available studies with zebra fish.
In a key study, acute fish toxicity of FAT 40147/E was assessed according to the internal Ciba method "Method A-11, Acute Fish toxicity", which is equivalent to OECD Guideline 203. Two groups of 10 zebra fish each, were exposed to test concentrations of 300 and 1000 mg/L for 96 hours. No mortality was observed with the concentration 300 mg/L throughout the observation period. However, 10 out of 10 fish were found to be dead with the concentration 1000 mg/L at the 96 hour observation. Hence, the LC50 was determined to be 620 mg/L.
In other three remaining supporting studies conducted on different batches of the test material, the 96 hour LC50 for FAT 40147 was determined to be >1000 mg/L.
Hence, the lowest value for 96 hour LC50 can be taken forward for hazard assessment to fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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