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EC number: 298-995-1 | CAS number: 93841-25-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Betoxol II degradation >10% was observed at all tested pH levels in a preliminary study so that further testing was necessary. Betoxol II was considered to be hydrolytically unstable at all tested conditions. An unknown transformation component was observed at a retention time of 1.6 min in the chromatograms. The maximum relative peak intensity found was 96% at pH 9.0 and 30 deg C calculated on a peak area basis relative to the initial peak area of Betoxol II. Identification of the component was not possible.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 13.9 h
- at the temperature of:
- 20 °C
Additional information
Hydrolysis as a function of pH for the test item Betoxol II was determined according to OECD guideline 111. The test was conducted with a test item concentration of 10 mg/L in buffer solutions of pH 5, 7 and 9 at temperatures of 20 and 30 deg C. Samples were taken at test start and at minimum of seven spaced points. Analyses of the test item Betoxol were performed by HPLC on a C18 column with sodium dodecyl sulphate as modifier and UV detection at 243nm. The test item Betoxol was determined to undergo hydrolysis at pH 5, 7 and 9 at 50 deg C based on the findings of a preliminary test. The rates of decline were >10% during 120h incubation under these conditions. In the definitive study (advanced testing for hydrolytically unstable substances) Betoxol II was found to undergo hydrolysis at all pH values (5, 7 and 9) and both tested temperatures (20 and 30 deg C). A major unknown transformation product was found at a retention time of 1.6 mins in the chromatograms. The maximum relative intensity of the unknown product was 96% of the applied Betoxol II concentration (calculated on peak area basis) at pH 9, 30 deg C and 7.1 hour of hydrolysis.
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