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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Estimated data generated using the EPI Suite model developed by the USEPA.
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
HYDROWIN Program (v2.00) from EPI Suite estimation database
GLP compliance:
no
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
HYDROWIN v2.00
Transformation products:
not specified
Temp.:
25 °C
DT50:
> 1 yr
Type:
other: estimated
Remarks on result:
other: pH and other details not known.

HYDROWIN Program (v2.00) Results:

================================

SMILES : C=CS(=O)(=O)c1ccc(cc1)Nc2nc(CL)nc(n2)Nc3cc(NC(=O)N)c(cc3)N=Nc4cc5c(S(

=O)(=O)O)cc(S(=O)(=O)O)cc5cc4S(=O)(=O)O([Na])

CHEM : 1,3,6-Naphthalenetrisulfonic acid, 7-[[2-[(aminocarbonyl)amino]-4-[[4

-chloro-6-[[4-(ethenylsulfonyl)phenyl]amino]-1,3,5

MOL FOR: C28 H21 CL1 N9 O12 S4 Na1

MOL WT : 862.21

--------------------------- HYDROWIN v2.00 Results ---------------------------

Hydrolyzable Function detected: Urea (Normal)

R-N-C(=O)-N-R

(where R is an alkyl, aromatic carbon or hydrogen substituent(s))

These types of ureas hydrolyze slowly with half-lives generally > 1 year.

Validity criteria fulfilled:
not specified
Conclusions:
Based on the QSAR prediction done using the EPI Suite HYDROWIN Program (v2.00), the half-life of of hydrolyzable functional group urea of the test substance was estimated to be > 1 year.
Executive summary:

Based on the QSAR prediction done using the EPI Suite HYDROWIN Program (v2.00), the half-life of hydrolyzable functional group urea of the test substance 1,3,6-Naphthalenetrisulfonic acid, 7-((2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)

amino)phenyl)azo)-, sodium salt was estimated to be > 1 year. Thus, based on this value, the substance was found to be not hydrolyzable.

Description of key information

Based on the QSAR prediction done using the EPI Suite HYDROWIN Program (v2.00), the half-life of hydrolyzable functional group urea of the test substance 1,3,6-Naphthalenetrisulfonic acid, 7-((2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)

amino)phenyl)azo)-, sodium salt was estimated to be > 1 year. Thus, based on this value, the substance was found to be not hydrolyzable.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information

Based on the QSAR prediction done using the EPI Suite HYDROWIN Program (v2.00), the half-life of hydrolyzable functional group urea of the test substance1,3,6-Naphthalenetrisulfonic acid,7-((2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)

amino)phenyl)azo)-, sodium saltwas estimated to be > 1 year. Thus, based on this value, the substance was found to be not hydrolyzable.