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REACH

Ethanol, 2-ethoxy-, manufacture of, by-products from

EC number: 310-288-2 | CAS number: 161907-78-4 A complex mixture of oxygenated hydrocarbons produced by the distillation of residues from the manufacture of ethylene glycol monoethyl ether. It consists predominantly of a mixture of di-, tri-, tetra- and pentaethylene glycol monoethyl ethers having carbon numbers predominantly in the range C6 to C12 and boiling in the range of approximately 200°C to 300°C (392°F to 572°F).

Life Cycle description
Uses advised against

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Data for 2-(2-(2-ethoxyyethoxy)ethoxy)ethanol:
- Pimephales Promelas: LC50(96hrs) >10000mg/l.
- Carrassius auratus: LC50(24 hrs) >5000mg/l. 
- QSAR prediction: LC50 = 32g/L
3,6,9,12-tetraoxatetradecan-1-ol
- QSAR prediction: LC50 = 73g/L

Key value for chemical safety assessment

Fresh water fish

Effect concentration:: 10 000 mg/L

Additional information

No data is available for the UVCB substance itself. A limited number of acute toxicity studies are available in fish for a major component of the substance, 2-(2-(2-ethoxyyethoxy)ethoxy)ethanol which show that it is practically non-toxic to fish. The LD50 was always in excess of the maximum tested dose. A reliable QSAR predicts that the LD50 of this substance is 32g/L and that the other major component, 3,6,9,12-tetraoxatetradecan-1-ol will be less toxic (LD50 73g/L). It therefore seems an acceptable conservative approach to use data from 2-(2-(2-ethoxyethoxy)ethoxy)ethanol in place of absent data for the UVCB substance itself.

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