Registration Dossier
Registration Dossier
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EC number: 413-390-6 | CAS number: 149144-85-4
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Generally accepted calculation method
Data source
Reference
- Reference Type:
- other: calculation
- Title:
- Bis(C12-13)alkyl-2-hydroxybutandioate - Calculation of the hydrolysis rate constant according to EPI Suite, Version 4.0; PC-Computer software developed by EPA's Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC)
- Author:
- Frijus-Plessen N.
- Year:
- 2 011
- Bibliographic source:
- EPIWIN (v 4.1), HYDROWIN Program (v 2.00)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- EPIWIN (v 4.1), HYDROWIN Program (v 2.00)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Results and discussion
- Details on hydrolysis and appearance of transformation product(s):
- Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v2.00]:Total Kb for pH > 8 at 25 deg C: 3.498 E-001 L/mol-sec
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 229.303 d
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 22.93 d
Applicant's summary and conclusion
- Conclusions:
- In aqueous media the substance is predicted to be hydrolysed with half-lives of 229 days at pH 7 and 23 days at pH 8.
- Executive summary:
Stability of the substanceagainst hydrolysis was calculated using the computer program HYDROWIN (v 2.00). A base-catalysed second-order hydrolysis rate constant of 0.3498 L/mole-sec was estimated using a structure estimation method. This corresponds to half-lives of 229 years at pH 7 and 23 days at pH 8.
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