Aluminium tridiethylphosphinate

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1998

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Deviations:

not specified

GLP compliance:

yes

Radiolabelling:

no

Analytical monitoring:

not specified

Duration:

30 h

pH:

4

Temp.:

22 °C

Initial conc. measured:

12.6 mg/L

Duration:

30 h

pH:

7

Temp.:

22 °C

Initial conc. measured:

10.8 mg/L

Duration:

30 h

pH:

9

Temp.:

22 °C

Initial conc. measured:

11.8 mg/L

Positive controls:

no

Transformation products:

no

Remarks on result:

hydrolytically stable based on preliminary test

Validity criteria fulfilled:

yes

Conclusions:

Because of the solubility characteristic of the test substance in water, in organic solvents and in buffers, the determination of the abiotic degradation, i.e. determination of the hydrolysis rate as a function of the pH-value, according to guideline 92/69/EEC, appendix, C.7 was impossible.

Pretest of the analogical Zn-salt and the corresponding acid of the substance of tests according OECD 111 at pH 4, 7 and 9 at 50°C indicate no hydrolysis (> 1 year).

It is therefore assumed that the hydrolysis of test item will be also > 1 year.
A refinement of the analytical methods makes it possible to start a new experiment. To make the value more robust we have started an experimental study to determine the hydrolysis rate as a function of pH according OECD Guideline 111 at pH 1, 4, 7 and 9.

Executive summary:

Because of the solubility characteristic of the test substance in water, in organic solvents and in buffers, the determination of the abiotic degradation, i.e. determination of the hydrolysis rate as a function of the pH-value, according to guideline 92/69/EEC, appendix, C.7 was impossible.

 

Pretest of the analogical Zn-salt and the corresponding acid of the substance of tests according OECD 111 at pH 4, 7 and 9 at 50°C indicate no hydrolysis (> 1 year).

 

It is therefore assumed that the hydrolysis of test item will be also > 1 year.

A refinement of the analytical methods makes it possible to start a new experiment.To make the value more robust we have started an experimental study to determine the hydrolysis rate as a function of pH according OECD Guideline 111 at pH 1, 4, 7 and 9.

 

Description of key information

Because of the solubility characteristic of the test substance in water, in organic solvents and in buffers, the determination of the abiotic degradation, i.e. determination of the hydrolysis rate as a function of the pH-value, according to guideline 92/69/EEC, appendix, C.7 was impossible.

 

Pretest of the analogical Zn-salt and the corresponding acid of the substance of tests according OECD 111 at pH 4, 7 and 9 at 50°C indicate no hydrolysis (> 1 year).

 

It is therefore assumed that the hydrolysis of test item will be also > 1 year.

A refinement of the analytical methods makes it possible to start a new experiment. To make the predicted value more robust we have started an experimental study to determine the hydrolysis rate as a function of pH according OECD Guideline 111 at pH 1, 4, 7 and 9.