Registration Dossier
Registration Dossier
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EC number: 435-860-1 | CAS number: 214417-91-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6 November - 5 December 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 92/69/EEC, A.6 (column elution method) (EEC publ. no L383, Dec 1992)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (1995)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 4.37 mg/L
- Temp.:
- 20 °C
- pH:
- 8.4
- Details on results:
- Preliminary test:
- concentration in water sample after 3 times centrifugation: 0.178 mg/l
- extra peak observed in HPLC-UV at approximately 3.5 minutes -> most likely originating from a (soluble) impurity in BMH
Main test:
- no test substance related response observed in the chromatogram of samples from the 'blank' columns
- concentrations in samples taken at flow rate 24 ml/h: mean value column 1: 4.15 mg/L, mean value column 2: 4.13 mg/L
- concentrations in samples taken at flow rate 12 ml/h: mean value column 1: 4.64 mg/L, mean value column 2: 4.55 mg/L
- overall mean (both columns and both flow-rates): 4.37 mg/L
- extra peak observed in HPLC-UV of all loaded carrier material column samples at approximately 3.5 minutes -> most likely originating from a (soluble) impurity in BMH (the lower the flow rate the higher the response)
- pH in pooled water samples varied between 8.3 and 8.5 - Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
The column elution method was used to determine the water solubility of BMH at 20.0 ± 0.5°C as 4.37x10^-3 g/L.
Reference
Description of key information
Water solubility of BMH at 20°C is 4.37 mg/L (EC A.6, OECD 105-Column elution method).
Key value for chemical safety assessment
- Water solubility:
- 4.37 mg/L
- at the temperature of:
- 20 °C
Additional information
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