Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 446-630-3 | CAS number: 181587-01-9
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The endpoint toxicity to birds is not a data requirement for the registered substance. However, for the sake of completeness this endpoint is covered by a short summary of the available data.
There are a total of 4 studies on the acute toxicity on birds available. All studies were performed under GLP conditions. Two studies investigated the acute oral toxicity to birds according to US EPA Subdivision E, Guideline 71 -1. Only one bird in the study with Anas platyhynchos was found dead after dosing. The 14-day LD50 values were > 2000 mg/kg based on nominal concentrations for Anas platyhynchos and Colinus virginianus. The other two acute studies investigated the dietary toxicity of Ethiprole and were conducted according to US EPA Subdivision E, Guideline 71 -2 and OECD guideline 205. No mortalities or clinical signs of toxicity were observed in the study with Anas platyhynchos, while one bird was found dead (at the concentration of 1300 mg/kg) in the study with Colinus virginianus. The 8-day LD50 values were > 5200 mg/kg based on nominal concentrations in Anas platyhynchos and Colinus virginianus. Additionally, three studies are available on the reproductive toxicity of Ethiprole towards Anas platyhynchos and Colinus virginianus. All studies were performed under GLP conditions. Two studies were performed according to US EPA Guideline 71-4. There were no significant differences detected in both studies between the control group and the treatment groups that were considered to be treatment related. The NOEC for reproduction was therefore determined to be 500 mg/kg in Colinus virginianus and Anas platyhynchos. The third study was conducted according to OECD guideline 206, OCSPP 850.2300, and EU Directive 91/414/EEC Regulation (EC) No. 1107/2009. The reproductive toxicity of Ethiprole was investigated in Colinus virginianus. The NOEL for both parental toxicity and reproduction endpoints in northern bobwhite quail exposed to Ethiprole was 800 mg/kg based on nominal concentrations, with a measured concentration of 842 mg a.i/kg feed or the mean achieved dose of 60 mg a.i./kg bodyweight/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
