Registration Dossier
Registration Dossier
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EC number: 479-330-6 | CAS number: 67226-45-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
3-hour EC50 of 430 mg/L and aNOEC of 100 mg/L.
Key value for chemical safety assessment
Additional information
A
study was performed to assess the effect of the test material on the
respiration of activated sewage sludge. The method followed that
described in the OECD Guidelines for Testing of Chemicals (1984) No 209
"Activated Sludge, Respiration Inhibition Test", Method C.1 of EEC
Commission Directive 88/302/EEC and US EPA Draft Ecological Effects Test
Guidelines OPPTS 850.6800. Data
indicated that the test material was known to react violently on contact
with water forming N-butylpyridinium chloride, hydrochloric acid and
alumina. The study was therefore mainly performed on the test material
degradation products and not the parent test material.
Following a preliminary range-finding test, activated sewage sludge was
exposed to an aqueous solution of the test material degradation products
at concentrations of 10, 32, 100, 320 and 1000 mg/L for a period of 3
hours at a temperature of approximately 21°C with the addition of a
synthetic sewage as a respiratory substrate.
The rate of respiration was determined after 30 minutes and 3 hours
contact time and compared to data for the control and a reference
material, 3,5-dichlorophenol.
The effect of the test material degradation products on the respiration of activated sewage sludge gave a 3-hour EC50 of 430 mg/L. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 100 mg/L.
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