Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 615-150-8 | CAS number: 707-37-9
Guidance on Safe Use
Guidance on Safe Use
Administrative data
First-aid measures
If inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If breathed in, give water to drink.
In case of skin contact: Immediately flush with plenty of water for at least 15 minutes. Wash clothing before reuse.
In case of eye contact: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
If swallowed: Never give anything by mouth to an unconscious person. Do not induce vomiting. Rinse mouth with water and give water to drink.
Most important symptoms and effects, both acute and delayed – to the best of our knowledge, the toxicological properties of the substance have not been fully investigated.
Irritating to eyes, respiratory system and skin. Substance may be harmful if swallowed. After contact with the eyes causes redness, tearing and itching or chemical conjunctivitis. Contact with the skin causes redness, itching or blistering. Irritating to respiratory mucous membranes.
Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
In case of skin contact: Immediately flush with plenty of water for at least 15 minutes. Wash clothing before reuse.
In case of eye contact: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
If swallowed: Never give anything by mouth to an unconscious person. Do not induce vomiting. Rinse mouth with water and give water to drink.
Most important symptoms and effects, both acute and delayed – to the best of our knowledge, the toxicological properties of the substance have not been fully investigated.
Irritating to eyes, respiratory system and skin. Substance may be harmful if swallowed. After contact with the eyes causes redness, tearing and itching or chemical conjunctivitis. Contact with the skin causes redness, itching or blistering. Irritating to respiratory mucous membranes.
Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
Fire-fighting measures
Extinguishing media:
Suitable extinguishing media:
Use water spray, dry chemical, carbon dioxide or appropriate foam.
Unsuitable extinguishing media: None.
Special hazards arising from the substance or mixture: Emits toxic fumes under fire conditions: carbon monoxide (CO), carbon dioxide (CO2) and other pyrolysis products typical of burning organic material. May emit corrosive fumes.
Advice for firefighters: Wear breathing apparatus plus protective gloves. Use water delivered as a fine spray to control fire and cool adjacent area. DO NOT approach containers suspected to be hot. Cool fire exposed containers with water spray from a protected location. If safe to do so, remove containers from path of fire. Equipment should be thoroughly decontaminated after use.
Suitable extinguishing media:
Use water spray, dry chemical, carbon dioxide or appropriate foam.
Unsuitable extinguishing media: None.
Special hazards arising from the substance or mixture: Emits toxic fumes under fire conditions: carbon monoxide (CO), carbon dioxide (CO2) and other pyrolysis products typical of burning organic material. May emit corrosive fumes.
Advice for firefighters: Wear breathing apparatus plus protective gloves. Use water delivered as a fine spray to control fire and cool adjacent area. DO NOT approach containers suspected to be hot. Cool fire exposed containers with water spray from a protected location. If safe to do so, remove containers from path of fire. Equipment should be thoroughly decontaminated after use.
Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment: wear self-contained breathing apparatus, rubber boots and heavy rubber gloves. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation.
For non-emergency personnel
Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation.
For emergency responders
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Environmental precautions
Do not let product enter drains, sewage system, reach ground water or water bodies.
Methods and material for containment and cleaning up
MINOR SPILLS: Remove all ignition sources. Clean up all spills immediately. Avoid contact with skin and eyes. Control personal contact by using protective equipment. Use dry clean up procedures and avoid generating dust. Place in a suitable, labelled container for waste disposal.
MAJOR SPILLS: Advise personnel in area. Alert Emergency Responders and tell them location and nature of hazard. Control personal contact by wearing protective clothing. Prevent, by any means available, spillage from entering drains or watercourses. Recover product wherever possible.
Use dry clean up procedures and avoid generating dust. Collect residues and place in sealed plastic bags or other containers for disposal. Wash area down with large amounts of water. If contamination of drains or waterways occurs, advise emergency services.
Use personal protective equipment: wear self-contained breathing apparatus, rubber boots and heavy rubber gloves. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation.
For non-emergency personnel
Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation.
For emergency responders
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Environmental precautions
Do not let product enter drains, sewage system, reach ground water or water bodies.
Methods and material for containment and cleaning up
MINOR SPILLS: Remove all ignition sources. Clean up all spills immediately. Avoid contact with skin and eyes. Control personal contact by using protective equipment. Use dry clean up procedures and avoid generating dust. Place in a suitable, labelled container for waste disposal.
MAJOR SPILLS: Advise personnel in area. Alert Emergency Responders and tell them location and nature of hazard. Control personal contact by wearing protective clothing. Prevent, by any means available, spillage from entering drains or watercourses. Recover product wherever possible.
Use dry clean up procedures and avoid generating dust. Collect residues and place in sealed plastic bags or other containers for disposal. Wash area down with large amounts of water. If contamination of drains or waterways occurs, advise emergency services.
Handling and storage
Precautions for safe handling
Avoid all personal contact, including inhalation. Wear protective clothing when risk of exposure occurs. Use in a well-ventilated area. Prevent concentration in hollows and sumps. DO NOT enter confined spaces until atmosphere has been checked. DO NOT allow material to contact humans, exposed food. Avoid contact with incompatible materials.
Keep containers securely sealed when not in use. Avoid physical damage to containers. Always wash hands with soap and water after handling. Work clothes should be laundered separately. Launder contaminated clothing before re-use. Use good occupational work practice. Observe manufacturer's storing and handling recommendations.
Conditions for safe storage, including any incompatibilities
Store away from incompatible substances. The substance is handled in closed systems under strictly controlled conditions. Recommended polyethylene or polypropylene container. Check all containers are clearly labelled and free from leaks. Store in original containers. Keep containers securely sealed. Protect containers against physical damage and check regularly for leaks.
Avoid all personal contact, including inhalation. Wear protective clothing when risk of exposure occurs. Use in a well-ventilated area. Prevent concentration in hollows and sumps. DO NOT enter confined spaces until atmosphere has been checked. DO NOT allow material to contact humans, exposed food. Avoid contact with incompatible materials.
Keep containers securely sealed when not in use. Avoid physical damage to containers. Always wash hands with soap and water after handling. Work clothes should be laundered separately. Launder contaminated clothing before re-use. Use good occupational work practice. Observe manufacturer's storing and handling recommendations.
Conditions for safe storage, including any incompatibilities
Store away from incompatible substances. The substance is handled in closed systems under strictly controlled conditions. Recommended polyethylene or polypropylene container. Check all containers are clearly labelled and free from leaks. Store in original containers. Keep containers securely sealed. Protect containers against physical damage and check regularly for leaks.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- Not dangerous good
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SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- Not dangerous good
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Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- Not dangerous good
Shipping information
- Proper shipping name and description:
- Not dangerous good
- Chemical name:
- Not dangerous good
- Labels:
- Not dangerous good
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- Not dangerous good
Shipping information
- Proper shipping name and description:
- Not dangerous good
- Chemical name:
- Not dangerous good
- Labels:
- Not dangerous good
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Exposure controls. Occupational exposure may occur through inhalation and dermal contact with this compound at workplaces where Memantine hydrochloride is produced or used.
Appropriate engineering controls – Local exhaust ventilation is required where solids are handled as powders or crystals. Exhaust ventilation should be designed to prevent accumulation and recirculation of particulates in the workplace.
Individual protection measures, such as personal protective equipment
Eye/face protection – For laboratory, larger scale or bulk handling or where regular exposure in an occupational setting occurs: chemical goggles.
Full-face shield may be required for supplementary but never for primary protection of eyes.
Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. This should include a review of lens absorption and adsorption for the class of chemicals in use and an account of injury experience.
Skin and body protection – Choose body protection according to the amount and concentration of the dangerous substance at the work place.
Hand protection – The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 and US F739. Suitability and durability of glove type is dependent on usage. Important factors in the selection of gloves include such as: frequency and duration of contact, chemical resistance of glove material, glove thickness and dexterity. When prolonged or frequently repeated contact may occur, a glove with a protection class of 5 or higher (breakthrough time greater than 240 minutes according to EN 374) is recommended.
When only brief contact is expected, a glove with a protection class of 3 or higher (breakthrough time greater than 60 minutes according to EN 374) is recommended. Contaminated gloves should be replaced.
Other – Barrier cream, skin-cleansing cream, eye wash unit.
Respiratory protection – Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Respirators may be necessary when engineering and administrative controls do not adequately prevent exposures. The decision to use respiratory protection should be based on professional judgment that takes into account toxicity information, exposure measurement data, and frequency and likelihood of the worker's exposure - ensure users are not subject to high thermal loads which may result in heat stress or distress due to personal protective equipment (powered, positive flow, full face apparatus may be an option). Certified respirators will be useful for protecting workers from inhalation of particulates when properly selected and fit tested as part of a complete respiratory protection program. Use approved positive flow mask if significant quantities of dust becomes airborne.
Appropriate engineering controls – Local exhaust ventilation is required where solids are handled as powders or crystals. Exhaust ventilation should be designed to prevent accumulation and recirculation of particulates in the workplace.
Individual protection measures, such as personal protective equipment
Eye/face protection – For laboratory, larger scale or bulk handling or where regular exposure in an occupational setting occurs: chemical goggles.
Full-face shield may be required for supplementary but never for primary protection of eyes.
Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. This should include a review of lens absorption and adsorption for the class of chemicals in use and an account of injury experience.
Skin and body protection – Choose body protection according to the amount and concentration of the dangerous substance at the work place.
Hand protection – The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 and US F739. Suitability and durability of glove type is dependent on usage. Important factors in the selection of gloves include such as: frequency and duration of contact, chemical resistance of glove material, glove thickness and dexterity. When prolonged or frequently repeated contact may occur, a glove with a protection class of 5 or higher (breakthrough time greater than 240 minutes according to EN 374) is recommended.
When only brief contact is expected, a glove with a protection class of 3 or higher (breakthrough time greater than 60 minutes according to EN 374) is recommended. Contaminated gloves should be replaced.
Other – Barrier cream, skin-cleansing cream, eye wash unit.
Respiratory protection – Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Respirators may be necessary when engineering and administrative controls do not adequately prevent exposures. The decision to use respiratory protection should be based on professional judgment that takes into account toxicity information, exposure measurement data, and frequency and likelihood of the worker's exposure - ensure users are not subject to high thermal loads which may result in heat stress or distress due to personal protective equipment (powered, positive flow, full face apparatus may be an option). Certified respirators will be useful for protecting workers from inhalation of particulates when properly selected and fit tested as part of a complete respiratory protection program. Use approved positive flow mask if significant quantities of dust becomes airborne.
Stability and reactivity
Reactivity – No dangerous reactions known.
Chemical stability – Stable under recommended storage conditions.
Possibility of hazardous reactions – Avoid contamination with oxidizing agents i.e. nitrates, oxidizing acids, chlorine bleaches, pool chlorine etc.
Conditions to avoid – Sources of ignition, moisture, light, heat.
Incompatible materials – Strong oxidizing and reducing agents, acid, bases.
Chemical stability – Stable under recommended storage conditions.
Possibility of hazardous reactions – Avoid contamination with oxidizing agents i.e. nitrates, oxidizing acids, chlorine bleaches, pool chlorine etc.
Conditions to avoid – Sources of ignition, moisture, light, heat.
Incompatible materials – Strong oxidizing and reducing agents, acid, bases.
Disposal considerations
Waste treatment methods – Contact a licensed professional waste disposal service to dispose of this material. All waste must be handled in accordance with local, state and federal regulations. Legislation addressing waste disposal requirements may differ by country, state and/ or territory. Each user must refer to laws operating in their area. Note that properties of a material may change in use, and recycling or reuse may not always be appropriate. Recycle wherever possible.
Consult Waste Management Authority for disposal if no suitable treatment or disposal facility can be identified. Dispose in Incineration in a licensed apparatus (after admixture with suitable combustible material). Decontaminate empty containers.
Consult Waste Management Authority for disposal if no suitable treatment or disposal facility can be identified. Dispose in Incineration in a licensed apparatus (after admixture with suitable combustible material). Decontaminate empty containers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
