1-[difluoro(trifluoromethoxy)methoxy]-1,2,2-trifluoroethylene

Density

Link to relevant study record(s)

Reference

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 18 February 2016 to 09 June 2016.

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

2008

Deviations:

yes

Remarks:

see below

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

2012

Deviations:

yes

Remarks:

see below

Principles of method if other than guideline:

Determination of density at 20°C using a pycnometer was not possible; due to continuous evaporation of the test item, weighing and therefore determination of density was not accurate. As an alternative, testing was performed at a lower temperature (i.e. 6 ± 1°C) using a volumetric flask with a volume of 25 mL. In order to prevent evaporation of test item, a solvent (water) with a lower density than the test item used. The volumetric flask was closed during weighing. With this method the density of the test item was calculated from the difference in weight between the full and empty volumetric flask and its volume.

GLP compliance:

yes

Type of method:

other: modified pycnometer method

Remarks:

A volumetric flask was used instead of a pycnometer.

Specific details on test material used for the study:

The substance is a volatile liquid.

Dynamic viscosity of test material:

no data

Key result

Type:

relative density

Density:

1.56 other: no dimension

Temp.:

6 °C

Type:

density

Density:

1.56 g/cm³

Temp.:

6 °C

Table: Volume of the pycnometer

 

	Test 1	Test 2	Mean
Mass empty volumetric flask	23.7200 g	23.7392 g	23.7296 g
Mass volumetric flask with water	48.7699 g	48.7954 g
Volume of the volumetric flask	25.0524 cm3	25.0587 cm3	25.0556 cm3

Table: Density of the test substance

	Test 1	Test 2	Mean
Mass empty volumetric flask	23.7277 g	23.7350 g
Mass volumetric flask with vehicle (water)	33.8273 g	36.9004 g
Mass volumetric flask with water and test item	57.1714 g	55.3916 g
Density [g/cm3]	1.561	1.555	1.56
Relative density	1.561	1555	1.56

Conclusions:

The relative density at 6°C of the substance MOVE3 was determined to be 1.56.

Executive summary:

The study was GLP compliant and based on EC A.3, OECD 109 and OPPTS 830.7300. However due to the test item properties (volatile liquid at ambient temperature), a deviation from these guidelines was observed during the study. Indeed determination of density at 20°C was not possible; due to continuous evaporation of the test item.

 

The density was determined at 6°C using a volumetric flask with a volume of 25 mL. In order to prevent evaporation of test item, a solvent (water) with a lower density than the test item was used. The volumetric flask was closed during weighing. With this method the density of the test item was calculated from the difference in weight between the full and empty volumetric flask and its volume.

The relative density was determined in duplicate at 6°C obtaining a mean value of 1.56.

Description of key information

The study was GLP compliant.

Due to the test item properties (volatile liquid at ambient temperature) a deviation from the standard guideline method EC A.3, OECD 109 and OPPTS 830.7300 occurred, indeed the determination of density at 20°C was not possible due to continuous evaporation of the test item.

The density was therefore determined at 6°C using a volumetric flask. The relative density was determined in duplicate at 6°C obtaining a mean value of 1.56.