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EC number: 925-894-8 | CAS number: 1174522-20-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Neurotoxicity
Administrative data
Description of key information
Acute CNS effects: NOAEC for in rats: 1500 to 2500 mg/m3 (based primarily on volatility)
Subchronic (13 weeks) neurotoxicity: NOAEC for rats: >24.3 g/m3 (6646ppm)
Key value for chemical safety assessment
Additional information
Four isoparaffinic hydrocarbon solvent products differing in predominant carbon number and volatility (C7-8, C8-9, C10-11, and C11-12) were tested for their acute effects on locomotor activity and operant performance after inhalation exposure in mice. For both measures, concentration effect curves were obtained for 30 min exposures using a within-subject design. The more volatile products, C7-8 and C8-9 isoparaffins, were easily vaporized under the test conditions. C10-11 isoparaffins were slowly volatilized and C11-12 isoparaffins could not be completely volatilized within the 30 min exposures, suggesting that acute human exposures may be less likely. C7-8, C8-9, and C10-11 isoparaffins produced reversible increases in locomotor activity of mice at 4000 and 6000 ppm and reversible decreases in rates of schedule controlled operant behavior in the same concentration range. The locomotor activity and operant behavior NOAEC for C7-8, C8-9, and C10-11 isoparaffins was determined to be 1000 ppm. The locomotor activity and operant behavior NOAEC for C11-12 isoparaffins was determined to be >2000 ppm as C11-12 isoparaffins did not produce acute CNS effects at the maximally attainable vapor concentrations.
In a battery of neurobehavioral tests, the NOAECs for acute CNS effects were determined to be >= 2500mg/m3 for cycloparaffins, >=1500mg/m3 for isoparaffins, and >=1500mg/m3 normal paraffins.
In a 13 week subchronic inhalation study, the neurotoxicity of light alkylate naphtha distillate (LAND-2; carbon range C5-C8) was examined in male and female rats. Locomotor activity and a functional operational battery were performed during the pretest week, weeks 5, 9, 14, and 18 (recovery group). Other than acute central nervous system effects, there were no treatment related neurotoxic effects in any of the treatment groups.
Justification for classification or non-classification
There are no chronic neurotoxicity specific studies for C9-C14 aliphatic, <2% aromatic hydrocarbon fluids. However, in a 13 week subchronic inhalation study, the neurotoxicity of light alkylate naphtha distillate (LAND-2; carbon range C5-C8) was examined in male and female rats and aside from acute CNS effects, no treatment related neurotoxic effects found in any of the treatment groups. The NOAEC was determined to be > 24.3 g/m3 (6646ppm). Additionally, no neurological effects were reported in the NTP 2 year carcinogenicity study on Stoddard solvent. Therefore, C9-C14 aliphatic, <2% aromatic hydrocarbon fluids are not likely to cause neurotoxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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