2-Naphthalenesulfonic acid, 7-amino-4-hydroxy-3-[[2-methoxy-5-methyl-4-[[2-(sulfooxy)ethyl]sulfonyl] phenyl]azo]-8-[[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-, tetrasodium salt

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as-
WoE 2. and WoE 3.

GLP compliance:

not specified

Radiolabelling:

not specified

Analytical monitoring:

not specified

Remarks:

WoE 2: no data available

pH:

4

Temp.:

50 °C

Remarks:

WoE 3: The study was performed at different pH i.e, 4, 7 and 9 and at 50⁰C

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

Remarks on result:

other: WoE 2: Test chemical was reported to be stable in water.

pH:

4

Temp.:

50 °C

Remarks on result:

other: WoE 3: Half-life value of test chemical is not known, but chemical is stable i.e not hydrolysed at pH 4, 7 and 9, respectively.

Details on results:

WoE 2: Test chemical was reported to be stable in water.
WoE 3: Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively and at a temperature of 50⁰C.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively and at a temperature of 50⁰C. Considering this result and as per the OECD TG 111 (Annnex 1), half-life of test chemical would be expected to be > 1 year at 25°C. Thus, test chemical was considered to be stable in water.

Executive summary:

Data available of the read across chemicals has been reviewed to determine the hydrolysis half-life value of the test chemical. The studies are as mentioned below:

The half-life of the test chemical was determined. Test chemical does not contain the functional group that hydrolyze in water. For hydrolysis to occur, the only reactivity in water involves desulfonation of the aromatic sulfonic acid or its corresponding sulfonic acid salt. In aqueous acid (sulfuric acid), aromatic sulfonic acids desulfonate at temperatures of 100 to 175 deg C. Although these conditions would not be typically encountered in the environment, it was reported that the test chemical is stable in water.

For the test chemical, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Although, half-life value of test chemical is not known, but chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively and at a temperature of 50⁰C. Considering this result and as per the OECD TG 111 (Annnex 1), half-life of test chemical would be expected to be > 1 year at 25°C.

On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively and at a temperature of 50⁰C. Considering this result and as per the OECD TG 111 (Annnex 1), half-life of test chemical would be expected to be > 1 year at 25°C. Thus, test chemical was considered to be stable in water.

Description of key information

On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively and at a temperature of 50⁰C. Considering this result and as per the OECD TG 111 (Annnex 1), half-life of test chemical would be expected to be > 1 year at 25°C. Thus, test chemical was considered to be stable in water.

Additional information

Data available of the read across chemicals has been reviewed to determine the hydrolysis half-life value of the test chemical. The studies are as mentioned below:

 

The half-life of the test chemical was determined. Test chemical does not contain the functional group that hydrolyze in water. For hydrolysis to occur, the only reactivity in water involves desulfonation of the aromatic sulfonic acid or its corresponding sulfonic acid salt. In aqueous acid (sulfuric acid), aromatic sulfonic acids desulfonate at temperatures of 100 to 175 deg C. Although these conditions would not be typically encountered in the environment, it was reported that the test chemical is stable in water.

 

For the test chemical, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Although, half-life value of test chemical is not known, but chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively and at a temperature of 50⁰C. Considering this result and as per the OECD TG 111 (Annnex 1), half-life of test chemical would be expected to be > 1 year at 25°C.

 

On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively and at a temperature of 50⁰C. Considering this result and as per the OECD TG 111 (Annnex 1), half-life of test chemical would be expected to be > 1 year at 25°C. Thus, test chemical was considered to be stable in water.