5,6-dimethoxyindoline

Guidance on Safe Use

First-aid measures

Skin contact: Immediately wash  skin with copious amounts of water for at least 15 minutes while removing. contaminated clothing and shoes. If irritation persists, seek medical attention.

Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes.  Assure adequate flushing  of  the  eyes  by  separating  the  eyelids  with  fingers. Ifirritation  persists,  seek  medical attention.

Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.

Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Fire-fighting measures

In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn.

Accidental release measures

Personal precautions:

Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards.

Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.

Respiratory precaution: Wear approved mask/respirator.

Hand precaution: Wear suitable gloves/gauntlets.

Skin protection: Wear suitable protective clothing.

Eye protection: Wear suitable eye protection.

Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal.

Environmental precautions: Do not allow material to enter drains or water courses.

Handling and storage

Handling:

This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet.

Storage:

Store in closed vessels.

Transport information

Shipping

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Shipping

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Marine transport (UN RTDG/IMDG)

Shipping

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Shipping

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Exposure controls / personal protection

Normal operation

Workers use PPE as a good practice to minimise possible exposures from minor accidental leaks during loading and unloading the reaction vessel, even though rigorous containment is ensured through technical means. Procedures are in place for disposal or cleaning of contaminated PPE.

Accident and incidents

A fully trained Emergency Response Team (ERT) is in place to react in case of accidents and incidents resulting in unexpected releases of the intermediate in order to minimize risks of exposures to humans and the environment. Components of the ERT are selected among senior site operators and technicians and are periodically trained and certified to respond to emergencies. Trainings and certifications of members ERT are subject to periodical revisions and approval by Local Fire Department. PPE as specified in emergency procedures and training are required in case of accidents and incidents. Procedures are in place for disposal or cleaning of contaminated PPE, as appropriate.

Maintenance and cleaning

Workers use additional PPE for cleaning the reaction vessel. A short exposure may occur during a maintenance operation, involving opening of a section of the pipeline connecting the reactor with loading station due to accidental presence of a residue of diluted intermediate that may lead to skin exposure. As a result, workers are given a specific work instruction on how to open this section, and are required to use high-efficiency PPE for skin and respiratory protection, as a precautionary and protective measure during all maintenance work, where there is a potential for exposure. PPE type is specified in the permit-to-work documents. Procedures are in place for disposal or cleaning of contaminated PPE, as appropriate.