Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 607-685-0 | CAS number: 252964-68-4
Flammability
Administrative data
- Endpoint:
- self-heating substances / mixtures
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-01-31 to 2017-05-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-(butan-2-yl)-4-{4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
- EC Number:
- 607-685-0
- Cas Number:
- 252964-68-4
- Molecular formula:
- C23H29N5O2
- IUPAC Name:
- 1-(butan-2-yl)-4-{4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): JNJ-7982559-AAA (T001329)
- Physical state: solid (powder)
- Appearance: Grey-brown powder
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: I14IB3639
- Analytical purity: 97.9% (based on HPLC)
- Expiration date: 2020-09-17
- Storage condition: at room temperature
Results and discussion
Self-heating substances / mixtures
- Key result
- Test procedure:
- 100 mm sample cube at 140°C
- Result:
- negative outcome (no effect observed)
Any other information on results incl. tables
A negative result was obtained. No spontaneous ignition occurred and no exothermic effect of the test item was observed. It demonstrated that the test item is “not a self-heating substance”. According to the UN guideline, no further testing is required. After the experiment, the test item had turned into a beige residue. It indicated that the test item had decomposed and/or reacted during the experiment.
Applicant's summary and conclusion
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- Self-heating of JNJ-7982559-AAA (T001329) was determined in accordance with UN Test N.4 “Test Method for Self-heating Substances”.
From the negative result obtained at 140°C using a 10 cm sample cube, it was concluded that JNJ-7982559-AAA (T001329) is not a self-heating substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
