1,2-Pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-dimethylethyl) ester, (2S)-

Guidance on Safe Use

First-aid measures

Description of necessary first-aid measures:

General information:
Pay attention to self-protection.
Remove victims from hazardous area.
Immediately remove soiled or soaked clothing and remove it to a safe distance.
Keep victim warm, in a stabilized position and covered.
Do not leave the victim unattended.
Place patients who are unconscious but breathing in the stabilized lateral position.

Respiratory Protection:

Inhalation:
Potential for exposure by inhalation if dusts or smoke are generated.
Move to fresh air.
With labored breathing:
Provide with oxygen.
Consult a doctor immediately.
If the casualty is not breathing:
Perform mouth-to-mouth resuscitation, notify emergency physician immediately.

Skin Contact:
Wash off affected area immediately with plenty of water for at least 15 minutes.
Get medical attention if any discomfort continues.

Eye contact:
With eye held open, thoroughly rinse immediately with plenty of water for at least 10 minutes.
Consult an ophthalmologist immediately if the symptoms persist.

Ingestion:
Rinse mouth.
Immediately give large quantities of water to drink.
Seek medical advice.

Personal Protection for First-aid Responders:
No data available.

Most important symptoms and effects, both acute and delayed:
Symptoms:
Irritation of skin and mucous membranes.
Hazards:
Irritant effects.

Indication of immediate medical attention and special treatment needed:
Treatment:
The initial focus is only on the local action, possibly characterized by a progressive tissue irritation.
In the eye, irritating solids cause, depending on the intensity of exposure, irritation of the conjunctiva and, in exceptional cases, damage to the cornea.
There is a danger of blindness if corneas are damaged!
Superficial irritations and only infrequent damage with ulcerations develop on the skin.

Fire-fighting measures

Extinguishing media:

Suitable extinguishing media:
All extinguishing substances suitable.

Unsuitable extinguishing media:
Do not use a solid water stream as it may scatter and spread fire.

Special hazards arising from the substance or mixture:
Danger of decomposition under influence of heat.

Hazard-determining flue gases might develop in case of fire:
-Carbon Dioxide
-Carbon Monoxide
-Nitrogen Oxides
Under certain conditions of combustion traces of other toxic substances cannot be excluded.

Advice for firefighters:
Special fire-fighting procedures:
In case of fire, remove the endangered containers and bring to a safe place, if this can be done safely.
Use water spray to cool unopened containers.
Water used to extinguish fire should not enter drainage systems, soil or stretches of water.
Contaminated extinguishing water must be treated at a suitable disposal plant in accordance with waste management laws.
Fire residues should be disposed of in accordance with the regulations.
Keep unauthorized personnel away.

Special protective equipment for fire-fighters:
In case of fire:
Full protective suit and wear a self contained respiratory apparatus.

Accidental release measures

Personal precautions, protective equipment and emergency procedures:
Keep unauthorized personnel away.

For non-emergency personnel:
No data available.

For emergency responders:
No data available.

Environmental Precautions:
Observe regulations on prevention of water pollution (check, dam up, cover up).
Do not allow entrance in sewage water, soil, stretches of water, drainage systems, surface water.
If the product contaminates rivers and lakes or drains inform respective authorities.

Methods and material for containment and cleaning up:
Accidental release measures Pick up mechanically.
Collect in suitable containers.
Pack and label wastes like the pure substance.
Do not detach label from the delivery containers prior to disposal.
Disposal according to local authority regulations.
To absorb spilled substance an approved industrial vacuum cleaner is recommended.
If necessary, the spilled substance should be moistened.

Handling and storage

Precautions for safe handling:
Technical measures (e.g. Local and general ventilation):
The substance must be handled under strictly controlled conditions in accordance with Article 17/18 of the REACH regulation.
Decant and handle product in separate areas only, e.g. use glove boxes, cabinets with differential pressure switch etc.
Ensure that dust-handling systems (such as exhaust ducts, dust collectors, vessels, and processing equipment) are designed in a manner to prevent the escape of dust into the work area (i.e., there is no leakage from the equipment).
Ensure suitable suction/aeration at the work place and with operational machinery.
Do not lead exhaust air back to workplace areas unfiltered.
Exhaust filter or scrubber: Exhaust air filter (HEPA-filter).

In case of dissolved solids:
Minimization of emissions by means of suitable technical measures such as flanges and valves with low leakage rates, recirculation of vapours.
Provide for installation of emergency shower and eye bath.
Do not add wastewater to a biological wastewater treatment plant.
Take precautionary measures against static discharges.
All precautionary measures indicated have to be observed.

Safe handling advice:
All precautionary measures indicated have to be observed.
Risk assessment and risk monitoring of all work places required.
Health, Safety and Emergency Management System recommended.
Regular safety training is a must.
Decant and handle product in separate areas only, e.g. use glove boxes, cabinets with differential pressure switch etc.
Ensure that apparatus and pipelines are free from leaks.
Do not ventilate into the open.
Maintain storage temperature.
Dedicated loading/unloading stations required.
The product should only be handled by trained personnel.
Empty, clean and dry system / system components completely before maintenance and repair work is done.
Written approval necessary in case of non-routine jobs, e.g. maintenance activities.
Handle in accordance with good industrial hygiene and safety practice.
Avoid residues of the product on the containers.
The personal protective equipment used must meet the requirements of Regulation (EU) 2016/425 and amendments (CE certification).
It should be defined in the work place in the form of a risk analysis according to Regulation (EU) 2016/425 and amendments.

Contact avoidance measures:
No data available.

Conditions for safe storage, including any incompatibilities:
Safe storage conditions:
Store in the original receptable, keeping this tightly sealed, under cool and dry conditions.
Normal measures for preventive fire protection.
Take precautionary measures against static discharges.
Ensure there are sufficient retaining facilities for water used to extinguish fire.
Protect from sunlight, warmth and heat.
In order to ensure due transportation, make certain that stacks are of the correct height, containers are securely fastened so as not to fall off, and labelled according to the regulations.
In the event of internal transportation, already-opened containers are to be kept closed in order to avoid spillage.

Safe packaging materials:
No data available.

Storage Class:
11: Combustible solids

 

Transport information

Land transport (UN RTDG/ADR/RID)

Shipping

Special provisions / remarks

Remarks:

Not regulated as a dangerous good.

Inland waterway transport (UN RTDG/ADN(R))

Shipping

Special provisions / remarks

Remarks:

Not regulated as a dangerous good.

Marine transport (UN RTDG/IMDG)

Shipping

Special provisions / remarks

Remarks:

Not regulated as a dangerous good.

Air transport (UN RTDG/ICAO/IATA)

Shipping

Special provisions / remarks

Remarks:

Not regulated as a dangerous good.

Additional transport information

Additional information

Special provisions / remarks / other:

Not regulated as a dangerous good.

Exposure controls / personal protection

Exposure controls:
Appropriate Engineering Controls:
The substance must be handled under strictly controlled conditions in accordance with Article 17/18 of the REACH regulation.
Decant and handle product in separate areas only, e.g. use glove boxes, cabinets with differential pressure switch etc.
Ensure that dust-handling systems (such as exhaust ducts, dust collectors, vessels, and processing equipment) are designed in a manner to prevent the escape of dust into the work area (i.e., there is no leakage from the equipment).
Ensure suitable suction/aeration at the work place and with operational machinery.
Do not lead exhaust air back to workplace areas unfiltered.
Exhaust filter or scrubber: exhaust air filter (HEPA-filter).

In case of dissolved solids:
Minimization of emissions by means of suitable technical measures such as flanges and valves with low leakage rates, recirculation of vapours.
Provide for installation of emergency shower and eye bath.
Do not add wastewater to a biological wastewater treatment plant.
Take precautionary measures against static discharges.
All precautionary measures indicated have to be observed.
Individual protection measures, such as personal protective equipment.

Eye/face protection:
Safety glasses with side-shields conforming to EN166 Accidental release measures If dust occurs:
Basket-shaped glasses.

Hand Protection:
Material: Nitrile.
Glove thickness: 0.11 mm
Guideline: DIN EN 374
Material: Nitrile/Chloroprene
Glove thickness: 0.65 mm
Guideline: DIN EN 374
Additional Information: Accidental release measures.
Additional Information: Selection of protective gloves to meet the requirements of specific workplaces.
The suitability for a specific workplace should be discussed with the producers of the protective gloves.
The information is based on our own tests, references from the literature and information from glove manufacturers, or derived by analogy with similar materials.
Be aware that in daily use the durability of a chemical resistant protective glove can be notably shorter than the break through time measured according to EN 374, due to the numerous outside influences (e.g. temperature).

Skin and Body Protection:
Usual lab protective clothing.
Accidental release measures: Chemical protection suit, single-use protection suit (antistatic).

Respiratory Protection:
Accidental release measures: Use respiratory equipment with suitable filter (filter type P3) or wear a self contained respiratory apparatus.
Note time limit for wearing respiratory protective equipment.

Hygiene measures:
Do not eat, drink, smoke, or sniff while at work.
Wash your hands and/or face before breaks and before termination of work.
Preventive skin protection is recommended.
Cleanse and apply cream to skin after work.
Take off contaminated clothing and wash it before reuse.

Environmental Controls:
In some cases, exhaust air scrubbers, filters or technical changes to the processing plant will be required in order to decrease emissions to acceptable values.

Stability and reactivity

Reactivity:
No data available.

Chemical Stability:
No data available.

Possibility of hazardous reactions:
No hazardous reactions are known if properly handled and stored.

Conditions to avoid:
No further information available.

Incompatible Materials:
No further information available.

Hazardous Decomposition Products:
-Carbon oxides
-Nitrogen Oxides

Disposal considerations

Waste treatment methods:
General information:
No data available.

Disposal methods:
Strictly controlled conditions during disposal or treatment to air, wastewater and waste.
Do not add wastewater to a biological wastewater treatment plant.
Bring wastewater containing AOX for professional disposal.
Bring used exhaust air filter for incineration.
Disposal according to local authority regulations.

Contaminated Packaging:
Do not reuse empty containers and dispose of in accordance with the regulations issued by the appropriate local authorities.