Registration Dossier
Registration Dossier
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EC number: 918-139-9 | CAS number: 1228577-90-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
A reproduction toxicity screening study (oral gavage) following the OECD guideline 421 is available for the endpoint.
Treatment with Diaminotoluene, propoxylated is not a reproductive toxicant at doses producing parental toxicity. The NOEL for reproductiv e toxicity is 160 mg/kg bw.
Diaminotoluene, propoxylated is not classifiable as hazardous in respect to its reproductive toxicity. There is sufficient information from a qualitative and quantitative understanding of the toxicological properties of the core substance, the repeating unit, and screening studies on the most bioavailable members of the category, such that testing for reproductive toxicity is not necessary. In view of this, no further testing is proposed (see also Illing & Barratt, 2009).
Short description of key information:
NOAEL (reproductive toxicity): ≥ 160 mg/kg bw.
Justification for classification or non-classification
The findings in the available study do not warrant classification according to the EU criteria.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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