Registration Dossier
Registration Dossier
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EC number: 920-750-0 | CAS number: -
Neurotoxicity
Administrative data
Description of key information
The weight of evidence based on a category approach indicates that hydrocarbons, C7 -C9, n-alkanes, isoalkanes, cyclics are unlikely to present a hazard as neurotoxicant.
Key value for chemical safety assessment
Additional information
No data are available on neurotoxic effects of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics. However, several members of the category have been tested, namely normal-heptane; n-octane; hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, < 5% n-hexane; hydrocarbons, C7-C9, isoalkanes; naphtha (petroleum), light alkylate (analogue substance for hydrocarbons, C7-C9, isoalkanes) and alkanes, C7-10-iso- (analogue substance for iso-octane). Studies on neurotoxic effects were performed in rodents upon single and/or repeated dose inhalation exposure to the test substances at maximum concentrations ranging from 12000 up to 24300 mg/m³. In the majority of cases, measurement of various parameters of neurobehavioral response showed minimal to no adverse effects. In some cases, however, reversible neurobehavioural effects occurred at the higher dose levels. NOAEC values for neurobehavioural effects were ≥ 1000 ppm (ca. 3500-5200 mg/m³ depending on composition), mice being much more sensitive than rats (Frantik et al., 1994; CEFIC, 2000, 2001; Lammers, 2001; Balster et al., 1997; Bowen and Balster, 1997; Schreiner et al. 1998).
Therefore, the substances in this category are unlikely to present a hazard as neurotoxicants.
References:
Balster, R. L. et al. (1997). Evaluation of the acute behavioral effects and abuse potential of a C8-C9 isoparaffin solvent. Drug and Alcohol Dependence 46: 125-135.
Bowen, S. E. and Balster, R. L. (1998). The Effects of Inhaled Isoparaffins on Locomotor Activity and Operant Performance in Mice. Pharmacology Biochemistry and Behavior, 61(3): 271-280.
CEFIC (2000). The Effects of Short-term Inhalatory Exposure to n-octane on Behaviour in the Rat. Unpublished. Testing laboratory: TNO Nutrition and Food Research Institute. Report no.: V99.429 Final. Owner company: CEFIC. Study number: 40.144/01.04. Report date: 2000-01-12.
CEFIC (2001). The Effects of Short-term Inhalatory Exposure to Iso-octane on Behaviour in the Rat. Unpublished. Testing laboratory: TNO Nutrition and Food Research Institute. Report no.: V99.430 Final. Owner company: CEFIC. Study number: 40.144/01.09. Report date: 2001-02-15.
Frantik, E. et al. (1994). Relative Acute Neurotoxicity of Solvents: Isoeffective Air Concentrations of 48 Compounds Evaluated in Rats and Mice. Environmental Research 66: 173-185.
Lammers, J. H. C. M. (2001). The Effects of Short-term Inhalatory Exposure to Cypar 7 on Behaviour in the Rat. Unpublished. Testing laboratory: TNO Nutrition and Food Research Institute. Report no.: V99.1115 Final. Owner company: CEFIC. Study number: 40.144/01.10. Report date: 2001-02-15.
Schreiner, C. et al. (1998). Toxicity evaluation of petroleum blending streams: inhalation subchronic toxicity/neurotoxicity study of a light alkylate naphtha distillate in rats. Journal of Toxicology and Environmental Health (Part A) 55:277-296.
Justification for classification or non-classification
The weight of evidence based on a category approach indicates that hydrocarbons, C7, n-alkanes, isoalkanes, cyclics are unlikely to present a hazard as neurotoxicant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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