Registration Dossier
Registration Dossier
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EC number: 700-105-8 | CAS number: 16613-04-0
Endpoint summary
Administrative data
Description of key information
A study according to OECD guideline 404 and a HET-CAM test were conducted. Both studies were conducted in compliance with GLP (incl. certificate). The test substance was not irritating to the skin of rabbits. In the HET-CAM test, the chorionallantoic membrane of the eggs did not show any irritation effects.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
A study in accordance with OECD guideline 404 with 3 rabbits demonstrated no irritation potential of the test material. Both the mean erythema value scores as well as the edema value scores of the 24-48-72 h time points were zero.
In the HET-CAM test the occurrence of vascular injury (haemorrhagia) or intravascular coagulation in response to the test substance was recorded. The chorionallantoic membrane of the eggs did not show a corrosive effect.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Because the substance shows no irritation potential to the skin of rabbits under the test conditions chosen, a classification is not warranted concerning this endpoint.
A corrosive effect on the chorionallantoic membrane of the fertilized eggs was not observed. Therefore, no evidence for serious eye damage is given under the test conditions chosen.
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