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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Component A (the major component of Y-513) has been tested. Component B where one methyl group located in the ortho position in the benzene ring is replaced by a sulphonate group in the para position, is present both as a calcium salt and an aluminium salt. Components C and D each lack, compared to Component B, one of the two methyl carbonyl groups. Considering the large molecular size of this molecule, the structural differences of component B, C and D relative to Component A are not considered to result in a significant different bioaccumulative potential. T, therefore an estimation of the bioaccumulation potential can be made based on the available study with Component A:
BCF at 1.0 mg/L: ≤ 0.5 L/kg
BCF at 0.1 mg/L: ≤ 5 L/kg
Based on these results, Y-513 is considered to have no potential for bioaccumulation.
Key value for chemical safety assessment
Additional information
The bioaccumulation of Component A (the major component of Y-513) in fish was determined under flow-through conditions in a study carried out according to the Japanese guideline "Test of Concentration Level of Chemical Substances in Fish and Shellfish“ regulated in "Methods of Testing New Chemical Substances“ (Notifications of Kanpogyo No. 5 Yakuhatsu No. 615 and Kikyaku No. 49 (392) dated July 13, 1974,as well as OECD305C (1981) and GLP.
Test substance and crystal sugar in an amount of 20-fold as much as the test substance were ground. Subsequently, HCO-40 in an amount of 50-fold as much as the test substance was added and ground. Then polyvinyl alcohol (degree of polymerization: approx. 500) in the same amount as the test substance was added and the mixture was dissolved in deionized water to prepare a 2000 mg/L stock dispersion.
This stock dispersion was aliquoted and diluted with ion exchanged water to 320 mg/L and 32 mg/L in the glass tank of dosing dispersion for the 1.0 mg/L and 0.1 mg/L test concentrations, respectively.
Per test concentration 12 fish were exposed in a 100L test vessel.
Water samples were taken twice a week. From each test concentration two fish were taken for analysis at t = 2, 3, 4 and 6 weeks, From the control, two fish were extracted and analysed by a HPLC-UV method
The measured concentration in water was ≥85% of the nominal concentration.
The measured concentration in fish was below the LOQ of 0.42 µg/g (assuming a fish weight of 30 g). Therefore the BCF values were calculated based on LOQ:
BCF at 1.0 mg/L:≤ 0.5 L/kg
BCF at 0.1 mg/L:≤ 5 L/kg
Y-513 consists of four major components (component A, B, C and D). Component A is the major component of Y-513. The other components (B, C and D) are the analogues of component A. Component B where one methyl group located in the ortho position in the benzene ring is replaced by a sulphonate group in the para position, is present both as a calcium salt and an aluminium salt. Components C and D each lack, compared to Component B, one of the two methyl carbonyl groups. Considering the large molecular size of this molecule, the structural differences of Component B, C and D relative to Component A are not considered to result in a significant different bioaccumulative potential.
The National Institute of Technology and Evaluation (NITE), Japan has performed bioaccumulation studies on Component A. On the basis of the results, the BCF of Y-513 is expected to have a similar value to those of the Component A. A possible explanation for the fact that the BCF value is low, although the Log Kow > 6.5 (the highest Log Kow of the reference substances of the OECD121 study), may be caused by a low bioavailability and/or steric hindrance due to the size of the substances.
In conclusion, Y-513 is considered to have no potential for bioaccumulation.
The validity criteria were fulfilled.
The study is rated Klimisch 2 (reliable with restrictions) because the study is carried out for component A only, whereas the results are used for Y-513, which is a mixture of component A and analogues.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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