2-Octen-1-ylsuccinic anhydride, mixture of cis and trans

Density

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

relative density

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

A category approach will be used for the hazard assessment of several endpoints. The hypothesis for the category of C8-12 Alkenyl Succinic Anhydrides is that data can be read-across among members of the category because their properties and behaviours are similar, based on common functional groups and similar breakdown products, and based on a constant pattern in changing of the potency of properties of the various carbon chain lengths. These features are in accordance with Annex XI, Section 1.5, of Regulation EC No. 1907/2006.  Common functional groups are: a dihydro-2,5 -furandione (cyclic anhydride) ring, carbon chain of length 8 to 12 carbons, with or without branching methyl groups, and a single double bond in the carbon chain, location unspecified. There are no additional functional groups which would contribute incremental or different toxicity.
 
The breakdown products are the dioic acids of the corresponding anhydride; these also have common functional groups. A constant pattern may also be displayed in acute toxicity, dermal irritancy and biodegradation, with the lowest carbon chain length (C8) displaying the highest activity. Irritation, toxicity and degradation potential diminish with increasing carbon chain length. Read-across among the category members is substantiated by the common behaviour in physico-chemical and toxicity behaviours, as provided in the Chemical Category Report Format (CCRF) attached to the IUCLID file. It is adequate to fulfill the information requirements of Annex IX, to be the basis for classification and labelling decisions, and for risk assessment.

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

GLP compliance:

no

Type of method:

air comparison pycnometer (for solids)

Type:

relative density

Density:

0.966 g/cm³

Temp.:

20 °C

Conclusions:

The density of octenyl succinic anhydride (0SA) is approximately 0.9663 g/cc, based on an experimental value from a close structural analogue, n-dodecenyl succinic anhydride. Data can be read-across among members of the C8-12 Alkenyl Succinic Anhydrides Category, based on common functional groups, similar break-down products and potency patterns among carbon-chain length. This is adequate to fulfill the information requirements, to be the basis for classification and labelling decisions, and for risk assessment.

Reference 2

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

GLP compliance:

no

Type of method:

air comparison pycnometer (for solids)

Type:

relative density

Density:

0.966 g/cm³

Temp.:

20 °C

Conclusions:

The density of octenyl succinic anhydride (0SA) is approximately 0.9663 g/cc, based on an experimental value from a close structural analogue, n-dodecenyl succinic anhydride. Data can be read-across among members of the C8-12 Alkenyl Succinic Anhydrides Category, based on common functional groups, similar break-down products and potency patterns among carbon-chain length. This is adequate to fulfill the information requirements, to be the basis for classification and labelling decisions, and for risk assessment.

Description of key information

Relative density is 0.9663

Key value for chemical safety assessment

Relative density at 20C:

0.966

Additional information

The relative density for octenyl succinic anhydride is proposed to be similar to that of n-dodecenyl succinic anhydride, based on common functional groups and similar breakdown products, and based on a constant pattern in changing of the potency of properties of the various carbon chain lengths. Functional groups include a dihydro-2,5 -furandione cyclic anhydride ring, a carbon chain of length 8 -12 carbons, and a single double-bond within the carbon chain. For category members with existing data on relative density, similar values are shown. The minor variation in the length of carbon chain is not anticipated to significantly alter density.