Registration Dossier
Registration Dossier
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EC number: 700-710-7 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
High quality NOEC/L(E)C10 values for chronic toxicity to freshwater fish are based on three fish species, Pimephales promelas,Oncorhynchus mykiss, and Brachydanio rerio. The NOEC or EC10 values that have been carried forward for the HC5-& PNEC derivation range between 40 and 134 µg Ni/L.
Chronic toxicity EC10 values are reported for two marine fish species and range from 3,599 μg Ni/L fto 20,760 μg Ni/L and have been carried forward for the HC5-& PNEC derivation.
Key value for chemical safety assessment
Additional information
Freshwater:
High quality NOEC/L(E)C10 values for chronic toxicity to freshwater fish are based on three fish species, Pimephales promelas,Oncorhynchus mykiss, and Brachydanio rerio. The NOEC/L(E)C10 values for fish range from 40 μg/l for Brachydanio rerio(Dave & Xiu, 1991) to 1,548 μg/l for the Oncorhynchus mykiss (Deleebeeck et al., 2005a).
The following table indicates those NOEC or EC10 values that have been carried forward for the HC5-& PNEC derivation
Key Study (freshwater Fish) |
Selected values for the most sensitive endpoints used for derivation of the freshwater HC5 |
||
Species |
Endpoint |
Value (ug/L) |
|
Birge et al., 1984 |
Pimephales promelas |
NOEC |
57 |
Nebeker et al., 1985 |
Oncorhynchus mykiss |
NOEC |
134 |
Dave & Xiu., 1991 |
Brachydanio rerio |
NOEC |
40 |
Marine:
Chronic toxicity values are reported for two marine fish species. EC10 values range from 3599 μg Ni/L for growth of the topsmelt, Atherinops affinis (Hunt et al., 2002), to 20760 μg Ni/L for growth of the sheepshead minnow, Cyprinodon variegatus(Golder et al., 2007).
Key Study (marine Fish) |
Selected values for the most sensitive endpoints used for derivation of the marine HC5 |
||
Species |
Endpoint |
Value (ug/L) |
|
Golder, 2005 |
Cyprinodon variegatus |
EC10 |
20, 760 |
Hunt et al., 2002 |
Atherinops affinis |
EC10 |
3,599 |
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