Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 24 Mar 97- 11 May 97
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Restriction due to the fact that the study was conducted on read-across substance.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Principles of method if other than guideline:
- Exceptions
1.This test method is appropriate for relatively pure substances. The test substance is a mixture therefore the results can only be considered an estimate.
2. A nonspecific analytical method, total organic carbon analysis was used to quantitate the test substance concentration in aqueous solution. The test substance was analyzed for percent carbon; this value and the results of TOC analysis of the aqueous solutions were used to calculate the test substance concentration in water. - GLP compliance:
- yes
- Dissociating properties:
- no
- Conclusions:
- The test substance was determined to have no observable dissociation.
- Executive summary:
The study was conducted to determine the dissociation constant of the test material. The test substance was equilibrated in water and the water soluble fraction was then titrated with a standard base. The average concentration of four replicates of test substance in water was 1.50 x 10-6 mole/Liter. The test substance titration curve for each of the four replicates was indistinguishable from the blank. The test substance was determined to have no observable dissociation. The result on the analogue material was considered to be appropriate for the Registration material.
- Endpoint:
- dissociation constant
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Dissociating properties:
- no
Referenceopen allclose all
Description of key information
A GLP study conducted in accordance with the OECD 112 guideline, dissociation constant- no observable dissociation.
Justification for selection - only one study available.
Key value for chemical safety assessment
Additional information
A GLP study conducted in accordance with the OECD 112 guideline, reported that the test substance was determined to have no observable dissociation. The result on the analogue material was considered to be appropriate for the Registration material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
