Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: assessment
Reference
Description of key information
No toxicokinetics studies are available for absorption of assessed substance. Based on its physico-chemcial properties, and available toxicological studies together with QSAR, assessed substance is estimated to be absorbed following oral administration with default value of 100%. Absorption via the dermal route is considered to be relevant with 100% for worst cases and inhalation absorption is estimated with low possibility via exposure to dust or vapor.
No experimental data on the distribution properties/metabolism/ excretion of assessed substance is available. Accumulation in fat tissue is expected to occur due to lipophilic substance (log P >0). QSAR Database indicated partitioning between the two tissues (brain/blood) at equilibrium is low. And QSAR Database also predicted no metabolism of assessed substance by CYP2C9 and CYP2D6 that are the main cytochromes involved in Humans xenobiotics metabolism.
The assessed substance is considered to be excreted in the urine due to water-soluble and low molecular weight.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
