Registration Dossier
Registration Dossier
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EC number: 942-835-1 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with the recommendations of REACh, the test was conducted according to the threshold approach recommended by ECHA. Using this approach the lowest EC50value from either the Algal Growth Inhibition study or Acute Toxicity to Daphnia magna study is set as the threshold concentration and a “Limit test” is conducted at this threshold concentration.
Exposure of rainbow trout (Oncorhynchus mykiss) to the test item gave LC50 values based on the nominal test concentrations of greater than 4.1 mg/L. The No Observed Effect Concentration was 4.1 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 4.1 mg/L
Additional information
In accordance with the recommendations of REACh, the test was conducted according to the threshold approach recommended by ECHA. Using this approach the lowest EC50value from either the Algal Growth Inhibition study or Acute Toxicity to Daphnia magna study is set as the threshold concentration and a “Limit test” is conducted at this threshold concentration
. If no mortalities are observed this indicates that fish are not the most sensitive species and that the LC50is greater than the threshold concentration. The EC50value obtained from the Algal Growth Inhibition study (Harlan Study Number 41402541) was the lowest of these two EC50values and hence the test was conducted at a single concentration of4.1 mg/L.
Seven fish were exposed to an aqueous solution of the test item, at a single concentration of 4.1 mg/L for a period of 96 hours at a temperature of approximately 14 ºC under semi-static test conditions. The number of mortalities and any sub-lethal effects of exposure in each test and control vessel were determined 3 and 6 hours after the start of exposure and then daily throughout the test until termination after 96 hours.
Analysis of the test preparations at 0, 24, 72 and 96 hours showed measured test concentrations to be near nominal and so the results are based on nominal test concentrations only.
Exposure of rainbow trout (Oncorhynchus mykiss) to the test item gave LC50values based on the nominal test concentrations of greater than 4.1 mg/L. The No Observed Effect Concentration was 4.1 mg/L.
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