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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1998
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Principles of method if other than guideline:
The test item was titrated with standard NaOH solution using an autotitrator at 22 °C. The pKa values were calculated using TableCurve 2D Automated Curve Fitting Software.
GLP compliance:
no
Dissociating properties:
yes
No.:
#1
pKa:
10.04
Remarks on result:
other: pK1
No.:
#2
pKa:
8.18
Remarks on result:
other: pK2
Conclusions:
Determined pK1 and pK2 values are 10.04 and 8.18, respectively.
Executive summary:

The test item was titrated with standard NaOH solution using an autotitrator at 22 °C. The pKa values were calculated and determined to be 10.04 (pK1) and 8.18 (pK2), respectively.

Description of key information

The test item was titrated with standard NaOH solution using an autotitrator at 22 °C. The pKa values were calculated and determined to be 10.04 (pK1) and 8.18 (pK2), respectively.

Key value for chemical safety assessment

pKa at 20°C:
10.04

Additional information