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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 January 2016 to 24 February 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP Guideline Study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Specific details on test material used for the study:
- - Physical state: yellow semi-solid
- Analytical purity: 100%
- Expiration date of the lot/batch: 23 November 2017
- Storage condition of test material: room temperature in the dark - Radiolabelling:
- no
- Test temperature:
- 30 °C
- Details on study design: HPLC method:
- EQUIPMENT
- Test utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
DETERMINATION OF DEAD TIME
- Method: The dead time was determined by measuring the retention time of formamide (purity: 99.94%) at 590 mg/L in methanol.
REFERENCE SUBSTANCES
- Solutions of reference standards were prepared in methanol (see table 6).
PREPARATION OF THE SAMPLE SOLUTION
- Test item (0.0555 g) was diluted to 100 mL with methanol to give a concentration of 0.555 g/L.
DETERMINATION OF RETENTION TIMES
- The sample, dead time and reference standard solutions were injected in duplicate using the high performance liquid chromatography (HPLC) parameters as attached. (See Retention time - HPLC parameters document, attached).
- The mobile phase was ramped to 100% tetrahydrofuran shortly after the elution of the last reference standard to elute the highly retained test item components. This was carried out for the sample and sample blank injections only.
EVALUATION OF DATA
Construction of the calibration curve:
- A calibration curve was constructed from the retention time data of the dead time and reference standard solutions (Figure 1, attached).
- Calculation of capacity factors k':
The capacity factors were determined using the following equation:
k’ = (tr– t0)/ t0
where:
k’: capacity factor; tr: retention time (min); t0: dead time (min)
- Calculation of adsorption coefficient:
Log10 Koc value was determined using the following equation:
Log10 Koc = Log10 k’ – A / B
Where:
Koc = adsorption coefficient; k’ = capacity factor; A = intercept of the calibration curve (figure 1, attached); B = slope of the calibration curve (figure 1, attached).
A correlation of log10 k’ versus Log10Koc of the calibration standards was plotted using linear regression. The capacity factor (k’) for the reference standards was calculated from the retention time data of the dead time and reference standard solutions. - Key result
- Type:
- Koc
- Value:
- < 17.8 dimensionless
- Temp.:
- 30 °C
- Key result
- Type:
- log Koc
- Value:
- < 1.25 dimensionless
- Temp.:
- 30 °C
- Details on results (HPLC method):
- - Typical chromatograms are attached.
- Retention times of the dead time and the retention times, capacity factors and log10 Koc values for the reference standards are shown in Tables7 (attached).
- The calibration curve is shown in Figure 1 (attached).
- The retention times, capacity factor and log10 Koc value determined for the sample are shown in Table 8 (attached). - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to be less than 17.8, log10 Koc <1.25.
- Executive summary:
Less than 17.8, log10Koc<1.25, using the HPLC screening method, designed to be compatible with C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
Reference
Description of key information
The adsorption coefficient (Koc) of the test item has been determined to be less than 17.8; log10 Koc <1.25 (OECD 121 and EU Method C.19). The result indicates that the substance has a very high mobility in soils (according to P.J. McCall et al., 1981).
Key value for chemical safety assessment
- Koc at 20 °C:
- 17.8
Additional information
Less than 17.8, log10 Koc <1.25, using the HPLC screening method, designed to be compatible with C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
The result indicates that the substance has a very high mobility in soils (according to P.J. McCall et al., 19811).
1McCall P.J., Laskowski D.A., Swann R.L., and Dishburger H.J., (1981), “Measurement of sorption coefficients of organic chemicals and their use, in environmental fate analysis”, in Test Protocols for Environmental Fate and Movement of Toxicants. Proceedings of AOAC Symposium, AOAC,
Washington DC.
Mobility classification scheme:
Range of Koc |
Mobility class |
0 - 50 |
Very high |
50 - 150 |
High |
150 - 500 |
Medium |
500 - 2000 |
Low |
2000 – 5000 |
Slightly |
> 5000 |
Immobile |
[LogKoc: 1.25]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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