Registration Dossier
Registration Dossier
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EC number: 944-062-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity, LD50: > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute Oral Toxicity
The acute oral toxicity was determined according to the EU Method B.1 (Acute Toxicity (Oral), in GLP.
In the Preliminary Study the test item was administered to one female at the dose of 500 mg/kg.
As no mortality was recorded in the animal, another female was administered atthe dose of 2000 mg/kg, and this too survived the treatment.
In the Main Study, five males and five females were treated at the dose of 2000 mg/kg and nomortality was recorded, hunched back, ataxia, irritability and liquid dark feaces were observed.
Justification for classification or non-classification
Acute oral toxicity
According to the CLP Regulation 1272/2008/EC, 3.1.2.1 section, substances can be allocated to one of four toxicity categories based on acute toxicity by the oral, dermal or inhalation route according to the numeric criteria shown in Table 3.1.1:
Oral (mg/kg body weight)
Category 1: LD50 ≤ 5
Category 2: 5 <LD50 ≤ 50
Category 3: 50 < LD50 ≤ 300
Category 4: 300 < LD50 ≤ 2 000
The oral LD50 values are > 2000 mg/kg/body weight.
The substance is not classified for oral toxicity because it doesn't meet the classification criteria of the CLP regulation n.1272/2008.
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