Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 946-056-8 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility for Cyprinodon variegatus (OECD 203); read-across
Key value for chemical safety assessment
Additional information
No study is available investigating the effects of the target substance Hexanedioic acid, di-C16-18 alkyl esters (CAS 92969-90-9) on freshwater fish. Thus, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substance Bis(tridecyl) adipate (CAS 16958-92-2) was conducted to fulfill the data requirements according to Annex VIII. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in within the analogue justification in IUCLID Section 13.
The available study investigated the toxicity of the source substance Bis(tridecyl) adipate (CAS 16958-92-2) to saltwater fish. The study was conducted under static conditions according to OECD guideline 203 using Cyprinodon variegatus as test organism. The test material was directly added to the test vessels preparing oil-water suspensions (OWD) in a range of 500 to 5000 mg/L. Undissolved test material was not removed, which bears the problem that observed effects could be related to physical interferences rather than systemic toxicity. There is no scientific basis to define a cut off limit value for solubility below which no toxicity could occur. There may be technical difficulties to perform the test, e.g. sensitivity of the analytical method used for the determination of test concentration. Tests above the limit of solubility should not be interpreted as pelagic toxicity, but as confounded by physical effects. However, this is considered negligible for this study, because the relevant effect value (LC50) after a 96 h test period is determined to be above the highest test concentration of 5000 mg/L.
Based on the structural and chemical similarity of the target and source substance, the target substance is expected to exhibit a similar ecotoxicological profile. Therefore, it can be concluded that the target substance Hexanedioic acid, di-C16-18 alkyl esters (CAS 92969-90-9) does not cause short-term effects to fish up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
