Registration Dossier
Registration Dossier
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EC number: 816-325-3 | CAS number: 5436-05-5
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The chronic toxicity to the freshwater fish species Pimephales promelas of the substance 1,3 -Bis (4 -hydroxy benzoyl) benzene was investigated under flow-through conditions in a GLP-compliant study performed in accordance with OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test). In addition, due to the low solubility of the test item, procedures were based on the test methods described in the OECD series on testing and assessment number 23, 2000.
Lethal and sub-lethal effects were assessed and compared with control values to determine the various effect concentrations. The results led to the following conclusions for the substance:
- the hatching success (embryonic survival) was not affected at concentrations up to and including 0.10 mg/L (NOEC). Hence the LOEC was >0.10 mg/L.
- Post-hatch survival (larval survival) was not affected at concentrations up to and including 0.10 mg/L (NOEC). Hence the LOEC was >0.10 mg/L.
- Growth of the epxosed larvae was not affected at concentrations up to and including 0.10 mg/L (NOEC). Hence the LOEC was >0.10 mg/L for both body weight and body length.
The reported effect concentrations are based on measured concentrations.
Key value for chemical safety assessment
Additional information
The chronic toxicity of 1,3 -Bis (4 -hydroxy benzoyl) benzene to the freshwater fish species Pimephales promelas was investigated under flow-through conditions in a GLP-compliant study performed in accordance with OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test). The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint.
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