Registration Dossier
Registration Dossier
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EC number: 833-052-5 | CAS number: 1175133-14-8
Endpoint summary
Administrative data
Description of key information
For this endpoint information from a structural similar compound is available. This study for this similar compound was performed according to GLP and the methods applied are fully compliant with OECD TG 429. The read across source test material was not a skin sensitiser under the test conditions of this study.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- For this endpoint information from a structural similar compound is available. This study for this similar compound was performed according to GLP and the methods applied are fully compliant with OECD TG 429. See chapter 13 report for a more detailed justification.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- SI
- Value:
- 1.6
- Test group / Remarks:
- 10%
- Key result
- Parameter:
- SI
- Value:
- 1.7
- Test group / Remarks:
- 25%
- Key result
- Parameter:
- SI
- Value:
- 1.3
- Test group / Remarks:
- 50%
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- For this endpoint information from a structural similar compound is available. The study for this similar compound was performed according to GLP and the methods applied are fully compliant with OECD TG 429. The Stimulation indices observed were below 3 thus no EC3 could be determined. Under the conditions of the OECD 429 assay the source compound was not a skin sensitiser.
See chapter 13 report for a more detailed justification.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the data provided, the test item is not classified for skin sensitization according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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