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EC number: 844-009-5 | CAS number: 167173-85-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypyridine-2-amido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate
- Cas Number:
- 167173-85-5
- Molecular formula:
- C26H30N2O9
- IUPAC Name:
- (3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypyridine-2-amido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate
Constituent 1
- Specific details on test material used for the study:
- Substance name: X642188
Lot#: SYN-FS08353-048
Purity: 99%
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 156 mg CaCO3/L
- Test temperature:
- 20.5 to 21.0°C
- pH:
- 6.9 to 7.1
- Dissolved oxygen:
- 6.9 to 8.4 mg/L (81 to 99% saturation)
- Conductivity:
- 470 μS/cm
- Nominal and measured concentrations:
- Nominal: 0 (control), 0 (vehicle control), 0.049, 0.11, 0.23, 0.52, 1.1, and 2.5 μg/L
Measured:
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.79 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Immobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1.3 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Immobility
- Remarks on result:
- other: Highest dose tested
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.33 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Immobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 48-h EC50 (Daphnia magna): 0.79 µg/L (Immobility)
- Executive summary:
The test substance was tested for acute toxicity to Daphnia magna at 48-h of exposure under flow-through conditions. The test was conducted according to OECD guideline 402.
Nominal concentrations used were 0 (control), 0 (vehicle control), 0.049, 0.11, 0.23, 0.52, 1.1, and 2.5 μg/L, corresponding to mean measured concentrations of <MQL (control), <MQL (vehicle control), 0.034, 0.068, 0.14, 0.33, 0.62, and 1.3 μg/L, respectively.
After 48 hours of exposure, immobility was 5% in the control and vehicle control, and 5, 0, 10, 0, 25, and 95% in 0.034, 0.068, 0.14, 0.33, 0.62, and 1.3 μg/L treatments, respectively. Daphnids not found were noted in the vehicle control, 0.14, and 1.3 μg/L test treatments at 24 hours, and in the vehicle control, 0.14, and 1.3 μg/L test treatments at 48 hours. Daphnids noted as not found at termination were considered dead and counted as immobile. No other sublethal effects were noted during the definitive test. There was a statistically significant increase in the immobility in the 0.62 and 1.3 μg/L test treatments compared to the pooled controls (Williams’ test, p ≤ 0.05). The 48-hour NOEC was 0.33 μg/L, based on the mean measured concentrations and the lack of statistically significant effects at this, and all lower test substance concentrations. The estimated 24-hour EC50 value was >1.3 μg/L, the highest concentration tested. The slope of the 24-hour concentration-response line was not calculated. The estimated 48-hour EC50 value was 0.79 μg/L, with 95% confidence limits of 0.66 and 0.95 μg/L. The slope of the 48-hour concentration-response line was 7.6.
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