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EC number: 844-009-5 | CAS number: 167173-85-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial plants
Administrative data
- Endpoint:
- toxicity to terrestrial plants: long-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 227 (Terrestrial Plant Test: Vegetative Vigour Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.4150 (Terrestrial Plant Toxicity Tier I (vegetative vigor))
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypyridine-2-amido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate
- Cas Number:
- 167173-85-5
- Molecular formula:
- C26H30N2O9
- IUPAC Name:
- (3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypyridine-2-amido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate
Constituent 1
- Specific details on test material used for the study:
- Substance name: X642188
Lot#: XS9-129333-47
Purity: 100%
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- yes
Test organisms
open allclose all
- Species:
- Lolium perenne
- Plant group:
- Monocotyledonae (monocots)
- Details on test organisms:
- Variety: Marabella
Common name: Ryegrass
- Species:
- Allium cepa
- Plant group:
- Monocotyledonae (monocots)
- Details on test organisms:
- Variety: Tamara
Common name: Onion
- Species:
- Brassica napus
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- Variety: Primus
Common name: Oilseed rape
- Species:
- Glycine max (G. soja)
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- Variety: Demetra
Common name: Soybean
- Species:
- Daucus carota
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- Variety: Napoli
Common name: Carrot
- Species:
- Cucumis sativus
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- Variety: Profi
Common name: Cucumber
- Species:
- Beta vulgaris
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- Variety: Wiebke
Common name: Sugar beet
- Species:
- Helianthus annuus
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- Variety: Extrasol
Common name: Sunflower
- Species:
- Lycopersicon esculentum
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- Variety: Golden Pearl
- Species:
- Avena sativa
- Plant group:
- Monocotyledonae (monocots)
- Details on test organisms:
- Variety: Aragon
Study design
- Test type:
- vegetative vigour test
- Study type:
- other: greenhouse
- Substrate type:
- natural soil
- Limit test:
- no
- Total exposure duration:
- 21 d
Test conditions
- Test temperature:
- 17.5 °C and 25.2 °C
- pH:
- 7.5
- Nominal and measured concentrations:
- Controls (Deionized water and PRESTO adjuvant), 32.5, 65, 130, 260 g a.i./ha
Results and discussion
Effect concentrationsopen allclose all
- Species:
- Beta vulgaris
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- 130 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Biomass (fresh weight)
- Remarks on result:
- other: Sugar beet showed significant fresh weight reduction of around 14% after application of 260.0 g/ha.
- Key result
- Species:
- other: Glycine max and Beta vulgaris
- Duration:
- 21 d
- Basis for effect:
- phytotoxicity
- Remarks on result:
- other: The tested plant species showed no phytotoxic symptoms except soybean and sugar beet. Very slight chlorosis and deformation were observed in soybean in all treatments treated with test substance. Sugar beet showed slight stunting after application of 260.
- Key result
- Species:
- Avena sativa
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- >= 260 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Plant survival
- Remarks on result:
- other: Highest dose tested
- Key result
- Species:
- Lolium perenne
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- >= 260 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Plant survival
- Remarks on result:
- other: Highest dose tested
- Key result
- Species:
- Allium cepa
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- >= 260 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Plant survival
- Remarks on result:
- other: Highest dose tested
- Key result
- Species:
- Brassica napus
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- >= 260 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Plant survival
- Remarks on result:
- other: Highest dose tested
- Key result
- Species:
- Glycine max (G. soja)
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- >= 260 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Plant survival
- Remarks on result:
- other: Highest dose tested
- Key result
- Species:
- Daucus carota
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- >= 260 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Plant survival
- Remarks on result:
- other: Highest dose tested
- Key result
- Species:
- Cucumis sativus
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- >= 260 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Plant survival
- Remarks on result:
- other: Highest dose tested
- Key result
- Species:
- Beta vulgaris
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- >= 260 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Plant survival
- Remarks on result:
- other: Highest dose tested
- Key result
- Species:
- Helianthus annuus
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- >= 260 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Plant survival
- Remarks on result:
- other: Highest dose tested
- Key result
- Species:
- Lycopersicon esculentum
- Duration:
- 21 d
- Dose descriptor:
- other: NOER
- Effect conc.:
- >= 260 g/ha
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Plant survival
- Remarks on result:
- other: Highest dose tested
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Plant survival: 21-d NOER (all species tested): >= 260 g a.i./ha (highest dose tested)
Phytotoxicity: Very slight chlorosis and deformation were observed in soybean in all treatments treated with test substance. Sugar beet showed slight stunting after application of 260.0 g a.i./ha.
Biomass: 21-d NOER (Beta vulgaris): 130 g a.i./ha - Executive summary:
A greenhouse trial was set up to obtain information on the sensitivity of 10 species of terrestrial plants. The effects on vegetative vigour were tested after application of the test substance at BBCH 12-14. The trial was conducted according to OPPTS 850.4150 and OECD guideline 227.
Soil (sieved to 2 mm) was natural soil from an agricultural area. The natural soil was silty loamy sand, which had been untreated with plant protection products and fertiliser for at least two years. For sugar beet cultivation the soil was pre-treated by steaming (>70°C) for more than 12 hours to reduce soil born diseases.
The trial was conducted in a greenhouse in Altfriesack, Brandenburg, Germany. This greenhouse is a chamber house with stony floor. Separate climate control for each chamber is based on an electronic system. All chambers can be illuminated and shaded when necessary.
The test was set up with 3 monocotyledonous and 7 dicotyledonous plant species. Germination tests were conducted prior to the start of the study to determine the viability of the seeds on filter paper.
A surplus of seeds was placed in each pot depending on germination ability. At BBCH 11-12 surplus plants were removed leaving the exact number of homogenous plants per pot for application.
Pots used were plastic containers with 10.5 cm, 12 cm or 14 cm in diameter (dependent on test species) not used before. Test crops were seeded several days before application to gain plants at BBCH stage 12-14.
The expected regime of temperatures between 12°C and 32°C was mainly held within this trial. The daily mean temperature ranged between 17.5°C and 25.2°C (extremes for short time only 11°C and 35°C. The daily mean relative humidity within the trial period ranged from 44.1 to 79.5% relative humidity (extremes 20 and 95%). The natural day length during the study period was adjusted to ≥16 hours by adding artificial light if outdoor light intensity was lower than 10 klux for 16 hours per day.
The test rates ranged between 32.5 g a.i./ha and 260 g a.i./ha. The factor between two subsequent rates was 2.
Plant survival was determined per pot 7, 14 and 21 days after treatment. For this the number of living and dead plants per pot was counted. To be considered alive, a plant had to have at least one green part on it.
Phytotoxicity assessments were done weekly after application following a scale of 0-10 where 0 means all plants dead and 10 excellent, good colour, no defects.
For biomass (fresh), all living plants of each pot were weighed together. Plants were cut directly at the soil surface. Dead plants were considered with a weight of 0 g. This assessment was done for all plant species within 24 hours after last irrigation. The weight was determined immediately after cutting the plant using a scale (type BA 310 P, Sartorius).
No plant mortality was observed for all tested plant species following the application of the test substance up to the highest tested rate at BBCH stage 12-14. The calculated NOER appeared to be higher than or equal 260 g a.i./ha. The ER50 value could not be calculated for plant survival, for any of the tested species.
The tested plant species showed no phytotoxic symptoms except soybean and sugar beet. Very slight chlorosis and deformation were observed in soybean in all treatments treated with the test substance. Sugar beet showed slight stunting after application of 260.0 g a.i./ha.
The plant biomass (shoot fresh weight) was determined 21 DAT. No influence of the test substance on plant weight was observed in oat, ryegrass, onion, oilseed rape, soybean, carrot, cucumber, sunflower and tomato. Sugar beet showed significant fresh weight reduction of around 14% after application of 260.0 g a.i./ha. The NOER for sugar beet was calculated to be 130.0 g a.i./ha. An ER50 was not detected for all tested plant species. No dose response could be found for all tested plant species.
Based on the results of this study, conducted under greenhouse conditions, it can be concluded that the test substance applied post emergence with rates up to 260 g a.i./ha did not cause adverse effects to plant mortality of all tested species and plant weight of oat, ryegrass, onion, oilseed rape, soybean, carrot, cucumber, sunflower and tomato.
The most sensitive plant species was found to be sugar beet. An ER50 level for fresh biomass reduction was not determined.
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