Registration Dossier
Registration Dossier
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EC number: 701-410-9 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Description of key information
Bioaccumulation: aquatic/sediment: the constituents of the submission substance have low potential for bioaccumulation
Key value for chemical safety assessment
Additional information
The constituents of the submission substance are expected to hydrolyse moderately to rapidly to form substances which have low log Kow values (<3) and thus have low potential for bioaccumulation. In addition, the constituents of the substance have low predicted log Kow values of <3. Therefore, in accordance with Column 2 of REACH Annex IX, the bioaccumulation in aquatic species study does not need to be conducted.
A measured BCF study is available for 3-aminopropyl(triethoxy)silane (CAS 919-30-2) which hydrolyses rapidly to form 3-aminopropylsilanetriol (Silanol HP-Z) and ethanol. A steady-state BCF value of 3.4 was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP. The test material supplied by the sponsor was easily hydrolysed in aqueous solution forming 3-aminopropyltrihydroxysilane. Therefore, it was considered that the test organisms are exposed to the 3-aminopropyltrihydroxysilane hydrolysis product (silanol HP-Z).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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