Registered substances

Registered substances

Registered substances

Please note:

As of end June 2022 we have processed and published all dossiers that had been pending since 14 October 2021. While daily processing has resumed there remains a processing queue. New submissions will be at the back of the processing queue, and may be slightly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
4-[(4-{[4-({5-[2-(acryloyloxy) ethoxy]-5-oxoalkanoyl}oxy) benzoyl]oxy}-2-methylaroxy)carbonyl] aryl 2-(acryloyloxy) ethyl alkandioate
- - Active Full Joint Tonnage data confidential 04-12-2017 View substance registered dossier
4-[(6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile
928-806-6 - Active Full Joint ≥ 1 to < 10 tonnes 29-05-2018 View substance registered dossier
4-[({(3R,3aR,6S,6aR)-6-[(4-{[4-({[4-(acryloyloxy)butoxy]carbonyl}oxy)benzoyl]oxy}benzoyl)oxy]hexahydrofuro[3,2-b]furan-3-yl}oxy)carbonyl]phenyl 4-({[4-(acryloyloxy)butoxy]carbonyl}oxy)benzoate
431-360-0 - Active NONS Individual Tonnage data confidential 02-08-2011 View substance registered dossier
4-[4-[4-[(3R, 5R)[5-(2,4-difluorophenyl) tetrahydro-5-(1H-1,2,4-triazol-1-yl-methyl)-furan-3-yl]methyloxy]phenyl]-1-piperazinyl]phenyl-2-[(1S,2S)(1-ethyl-2-phenylmethoxypropyl)]-2,4-dihydro-3Htriazol-3-one
938-153-9 - Active Full Joint ≥ 1 to < 10 tonnes 27-06-2017 View substance registered dossier
4-[bis(2-tert-butyl-4-hydroxy-6-methylphenyl)methyl]phenyl 6-diazo-5-oxo-5,6-dihydronaphthalene-1-sulfonate
451-040-4 - Active NONS Individual Tonnage data confidential 27-11-2012 View substance registered dossier
4-[bis(phenylsubstituted)substituted]phthalic acid
- - Active Full Joint ≥ 1 to < 10 tonnes 02-06-2020 View substance registered dossier
4-[difluoro(3,4,5-trifluorophenoxy)methyl]-2',3,5-trifluoro-4''-pentyl-1,1':4',1''-terphenyl
935-977-0 - Active Full Joint ≥ 0 to < 10 tonnes 16-10-2019 View substance registered dossier
4-acetilammino-N-((1-etil-2pirrolidinil)metil) -5 etilsulfonil-2-metossi benzamide
925-003-2 - Active Intermediate Joint Intermediate use only 27-03-2018 View substance registered dossier
4-acetyl-N-[(4R)-2-ethyl-3-oxo-1,2-oxazolidin-4-yl]-2-methylbenzamide
- - Active Intermediate Joint Intermediate use only 28-06-2022 View substance registered dossier
4-Amino-2,3-dichlorophenol
464-070-8 - Active Intermediate Joint Intermediate use only 28-09-2021 View substance registered dossier
4-amino-5-ethyl-1-(2-methoxyethyl)-1H-Pyrazole-3-carboxamide
438-910-9 - Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
4-bromo-2,3',4',5'-tetrafluoro-1,1'-biphenyl
936-926-5 - Active Intermediate Joint Intermediate use only 19-02-2018 View substance registered dossier
4-butoxy-2,2,6,6-tetramethyl-1-piperidinyloxy
482-430-2 - Active Full Individual ≥ 0 to < 10 tonnes 24-03-2021 View substance registered dossier
4-Butoxy-2,3-difluor-4'-methyl-1,1'-biphenyl
938-422-0 - Active Full Joint ≥ 0 to < 10 tonnes 13-05-2019 View substance registered dossier
4-Butoxy-4'-ethoxy-2',3,3'-trifluoro-[1,1'-biphenyl]-2-ol
- - Active Intermediate Joint Intermediate use only 21-06-2022 View substance registered dossier
4-chloromethyl-4''-ethyl-2'-fluoro-[1,1':4',1''-terphenyl]
- - Active Full Joint ≥ 1 to < 10 tonnes 05-07-2022 View substance registered dossier
4-cis-ethyl-4'-trans-propyl-[1,1'-bicyclohexyl]
935-545-1 - Active Intermediate Joint Intermediate use only 19-02-2018 View substance registered dossier
4-CPH
428-130-7 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-ethoxy-2,3-difluoro-4'-(trans-4-propylcyclohexyl)-1,1'-biphenyl
921-136-5 - Active Full Joint ≥ 0 to < 10 tonnes 16-04-2018 View substance registered dossier
4-Ethyl-3'-fluorobiphenyl
918-150-9 - Active Intermediate Joint Intermediate use only 31-03-2021 View substance registered dossier
4-hydroxy-3-methyl-5-[(1R)-2,2,3-trimethylcyclopent-3-en-1-yl]pentan-2-one
949-712-1 - Active Intermediate Joint Intermediate use only 11-02-2019 View substance registered dossier
4-hydroxybutan-2-one + 3-(hydroxymethyl)but-3-en-2-one
908-868-0 - Active Intermediate Joint Intermediate use only 22-01-2020 View substance registered dossier
4-hydroxystyrene, 4-tbutoxy styrene and styrene copolymer
433-660-7 - Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
4-Methoxy-5-(3-morpholin-4-yl-propoxy)-2-nitro-benzonitrile
936-067-6 - Active Intermediate Joint Intermediate use only 24-10-2017 View substance registered dossier
4-Methoxy-N-(3-N',N'-dimethylaminopropyl) naphthalimide 2-hydroxy-3-allyloxypropyl ammonium hydroxide
461-080-4 - Active NONS Individual Tonnage data confidential 06-09-2010 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Rolic Technologies B.V. Luchthavenweg 10 5657 EB Eindhoven Netherlands Netherlands Active 4-[(4-{[4-({5-[2-(acryloyloxy) ethoxy]-5-oxoalkanoyl}oxy) benzoyl]oxy}-2-methylaroxy)carbonyl] aryl 2-(acryloyloxy) ethyl alkandioate - - - View substance registered dossier
Janssen Pharmaceutical Science Unlimited Company Little Island County NA Cork Ireland Ireland Active 4-[(6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile 928-806-6 - - View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Active 4-[({(3R,3aR,6S,6aR)-6-[(4-{[4-({[4-(acryloyloxy)butoxy]carbonyl}oxy)benzoyl]oxy}benzoyl)oxy]hexahydrofuro[3,2-b]furan-3-yl}oxy)carbonyl]phenyl 4-({[4-(acryloyloxy)butoxy]carbonyl}oxy)benzoate 431-360-0 - 2011 View substance registered dossier
Schering-Plough (Ireland) Company Avondale Co Wicklow Avondale Co. Wicklow Ireland Ireland Cease Manufacture 4-[4-[4-[(3R, 5R)[5-(2,4-difluorophenyl) tetrahydro-5-(1H-1,2,4-triazol-1-yl-methyl)-furan-3-yl]methyloxy]phenyl]-1-piperazinyl]phenyl-2-[(1S,2S)(1-ethyl-2-phenylmethoxypropyl)]-2,4-dihydro-3Htriazol-3-one 938-153-9 - 2022 View substance registered dossier
MSD International GmbH (Ballydine Branch) Ballydine - Kilsheelan 0 Clonmel Ireland Ireland Active 4-[4-[4-[(3R, 5R)[5-(2,4-difluorophenyl) tetrahydro-5-(1H-1,2,4-triazol-1-yl-methyl)-furan-3-yl]methyloxy]phenyl]-1-piperazinyl]phenyl-2-[(1S,2S)(1-ethyl-2-phenylmethoxypropyl)]-2,4-dihydro-3Htriazol-3-one 938-153-9 - 2015; 2017 View substance registered dossier
- - - - 4-[bis(2-tert-butyl-4-hydroxy-6-methylphenyl)methyl]phenyl 6-diazo-5-oxo-5,6-dihydronaphthalene-1-sulfonate 451-040-4 - - View substance registered dossier
Covance Clinical Development SA 024 Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain Spain Active 4-[bis(phenylsubstituted)substituted]phthalic acid - - 2020 View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-[difluoro(3,4,5-trifluorophenoxy)methyl]-2',3,5-trifluoro-4''-pentyl-1,1':4',1''-terphenyl 935-977-0 - 2019 View substance registered dossier
ICROM S.r.l Via delle arti, 33 20863 Concorezzo Italy Italy Active 4-acetilammino-N-((1-etil-2pirrolidinil)metil) -5 etilsulfonil-2-metossi benzamide 925-003-2 - - View substance registered dossier
Saltigo GmbH HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany Germany Active 4-acetyl-N-[(4R)-2-ethyl-3-oxo-1,2-oxazolidin-4-yl]-2-methylbenzamide - - 2022 View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active 4-Amino-2,3-dichlorophenol 464-070-8 - 2010 View substance registered dossier
Saltigo GmbH HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany Germany Active 4-Amino-2,3-dichlorophenol 464-070-8 - 2011; 2021 View substance registered dossier
- - - - 4-amino-5-ethyl-1-(2-methoxyethyl)-1H-Pyrazole-3-carboxamide 438-910-9 - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-bromo-2,3',4',5'-tetrafluoro-1,1'-biphenyl 936-926-5 - - View substance registered dossier
Nufarm GmbH & Co.KG OR St.-Peter-Str.25 4021 Linz Austria Austria Active 4-butoxy-2,2,6,6-tetramethyl-1-piperidinyloxy 482-430-2 - 2014; 2016; 2021 View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-Butoxy-2,3-difluor-4'-methyl-1,1'-biphenyl 938-422-0 - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-Butoxy-4'-ethoxy-2',3,3'-trifluoro-[1,1'-biphenyl]-2-ol - - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-chloromethyl-4''-ethyl-2'-fluoro-[1,1':4',1''-terphenyl] - - 2018; 2022 View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-cis-ethyl-4'-trans-propyl-[1,1'-bicyclohexyl] 935-545-1 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 4-CPH 428-130-7 - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-ethoxy-2,3-difluoro-4'-(trans-4-propylcyclohexyl)-1,1'-biphenyl 921-136-5 - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-Ethyl-3'-fluorobiphenyl 918-150-9 - 2021 View substance registered dossier
TAKASAGO TICSA-Producer/Importer Avenida de Mazarrón, 49 30120 El Palmar Murcia Spain Spain Active 4-hydroxy-3-methyl-5-[(1R)-2,2,3-trimethylcyclopent-3-en-1-yl]pentan-2-one 949-712-1 - - View substance registered dossier
DSM Nutritional Products GmbH - OR1 Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany Germany Active 4-hydroxybutan-2-one + 3-(hydroxymethyl)but-3-en-2-one 908-868-0 - 2020 View substance registered dossier
- - - - 4-hydroxystyrene, 4-tbutoxy styrene and styrene copolymer 433-660-7 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. - - Active 4-hydroxystyrene, 4-tbutoxy styrene and styrene copolymer 433-660-7 - - View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Active 4-Methoxy-5-(3-morpholin-4-yl-propoxy)-2-nitro-benzonitrile 936-067-6 - - View substance registered dossier
Nalco Italiana Manufacturing S.r.l. Via Ninfina II° 04012 Cisterna di Latina Italy Italy Active 4-Methoxy-N-(3-N',N'-dimethylaminopropyl) naphthalimide 2-hydroxy-3-allyloxypropyl ammonium hydroxide 461-080-4 - 2010 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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