Registered substances

Registered substances

Registered substances

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

Please note:
  • The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
  • Please be aware that the annual IUCLID format change is coming soon. We will be adapting the Dissemination platform to the new format, which means that as of 15th October 2021 until early 2022 there will be a break in publication of newly submitted registration dossiers. We appreciate your understanding in this matter.
Last updated 13 October 2021. Database contains 23445 unique substances and contains information from 104978 dossiers.
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Details
4,4'-(2,3-epoxypropoxy)-2,2'- dimethyl-5,5'-tert-butyldiphenylsulphide
441-520-1 - Active Full Joint ≥ 1 to < 10 tonnes 10-09-2018 View substance registered dossier
4,4'-[(6S)-6-phenylindolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis{2-[(2S)-2-pyrrolidiniumyl]-1H-imidazol-3-ium} tetrachloride
944-036-3 - Active Intermediate Individual Intermediate use only 21-10-2016 View substance registered dossier
4,4'-[1,2-ethenediylbis[(3-sulfo-4,1-phenylene)imino[6-[bis(2-hydroxyethyl)amino]-1,3,5-triazine-4,2-diyl]imino]]bisarenoate sodium salt
- - Active Full Individual ≥ 1 000 to < 10 000 tonnes 23-07-2013 View substance registered dossier
4,4'-bis(2-methyl-2-(4-methylphenyl)-1-propionyl)diphenylsulfide
415-410-9 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4,4'-carbonylbis[2-({[3-(triethoxysilyl)propyl]amino}carbonyl)benzoic acid]
419-190-5 - Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
4,4'-methylene bis(3-chloro-2,6-di-ethylphenylisocyanate)
420-530-1 - No longer Valid NONS Individual No longer valid 15-12-2008 View substance registered dossier
4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol
701-072-2 - Active Full Joint ≥ 1 000 to < 10 000 tonnes 28-05-2021 View substance registered dossier
4,4'-methylenediphenyldiisocyanate and 2,4'-diisocyanatodiphenylmethane and their oligomerisation reaction products with 2,2'-oxydiethanol, propane-1,2-diol and butane-1,3-diol
701-276-1 - Cease Manufacture Full Joint Cease manufacture 13-02-2019 View substance registered dossier
4,4,19,19-tetraethoxy-3,20-dioxa-8,15-dithia-4,19-disiladocosaneand S-(6-{[3-(triethoxysilyl)propyl]thio}hexyl) ethanethioate
951-696-6 - Active Full Joint ≥ 1 to < 10 tonnes 22-02-2021 View substance registered dossier
4,4’-isopropylidenediphenol, reaction products with 1-chloro-2,3-epoxypropane, mono, di and triesters with acrylic acid
948-054-2 - Active Full Joint ≥ 1 to < 10 tonnes 21-10-2019 View substance registered dossier
4,5-di-tert-butyl-6-ethoxy-2,2-dimethyl-3,7-dioxa-4-aza-6-phosphanonan-1-oic acid 6-oxide
449-920-8 - Active NONS Individual Tonnage data confidential 16-12-2010 View substance registered dossier
4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol
443-400-4 - Active Intermediate Joint Intermediate use only 20-08-2018 View substance registered dossier
4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol
443-400-4 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-(4-{2-[1,2,7,8-tetrahydro-7-(4-nitro-2-sulfophenylhydrazono)-1,8-dioxo-3,6-disulfo-2-naphthylidene]hydrazino}-3-sulfophenylhydrazono)pyrazole-3-carboxylic acid, lithium sodium salt
445-080-1 - No longer Valid NONS Individual No longer valid 24-11-2010 View substance registered dossier
4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-(4-{2-[1,2,7,8-tetrahydro-7-(4-nitro-2-sulfophenylhydrazono)-1,8-dioxo-3,6-disulfo-2-naphthylidene]hydrazino}-3-sulfophenylhydrazono)pyrazole-3-carboxylic acid, lithium sodium salt
445-080-1 - Active NONS Individual Tonnage data confidential 29-04-2021 View substance registered dossier
4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate)
407-410-2 - Active Full Individual ≥ 100 to < 1 000 tonnes 08-12-2016 View substance registered dossier
4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate)
407-410-2 - Active NONS Joint Tonnage data confidential 09-11-2011 View substance registered dossier
4-(1-((3-((2-(tert-butoxycarbonyl(methyl)amino)acetoxy)methyl)pyridin-2-yl)(methyl)carbamoyloxy)ethyl)-1-((2R,3S)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium)hemisulphate
926-418-1 - Active Intermediate Individual Intermediate use only 09-05-2018 View substance registered dossier
4-(2-aminoethyl)indole, fumarate
947-445-5 - Active Intermediate Joint Intermediate use only 07-05-2018 View substance registered dossier
4-(2-carboxymethylthio)ethoxy-1-hydroxy-5-isobutyloxycarbonylamino-N-(3-dodecyloxypropyl)-2-naphthamide
420-730-7 - Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
4-(4'-Trifluoromethylphenyl)benzaldehyde
473-430-3 - Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
4-(4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-1-butynyl)-.alpha.,.alpha.-dimethylbenzeneacetic acid
462-560-6 - No longer Valid Intermediate Individual No longer valid 10-05-2011 View substance registered dossier
4-(4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-1-butynyl)-.alpha.,.alpha.-dimethylbenzeneacetic acid
462-560-6 - Active Intermediate Joint Intermediate use only 06-07-2015 View substance registered dossier
4-(4-aminoanilino)-6-[3-(dibutylamino)propylamino]-heteromonocyclic-2-ol
427-670-0 - Active Full Joint ≥ 1 tonnes 24-03-2016 View substance registered dossier
4-(4-Brom-5-ethyl-tetrahydropyran-2-yl)-phenol
919-822-4 - Active Intermediate Joint Intermediate use only 25-05-2018 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
ExponentOR35I Block 1, Blanchardstown Corporate Park Ballycoolen Road, Blanchardstown D15 AKK1 Dublin Ireland Ireland Active 4,4'-(2,3-epoxypropoxy)-2,2'- dimethyl-5,5'-tert-butyldiphenylsulphide 441-520-1 - 2018 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active 4,4'-[(6S)-6-phenylindolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis{2-[(2S)-2-pyrrolidiniumyl]-1H-imidazol-3-ium} tetrachloride 944-036-3 - - View substance registered dossier
[Confidential] - - - 4,4'-[1,2-ethenediylbis[(3-sulfo-4,1-phenylene)imino[6-[bis(2-hydroxyethyl)amino]-1,3,5-triazine-4,2-diyl]imino]]bisarenoate sodium salt - - - View substance registered dossier
- - - - 4,4'-bis(2-methyl-2-(4-methylphenyl)-1-propionyl)diphenylsulfide 415-410-9 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Belgian competent national authority. - - Active 4,4'-carbonylbis[2-({[3-(triethoxysilyl)propyl]amino}carbonyl)benzoic acid] 419-190-5 - - View substance registered dossier
Lonza Biologics PLC The Courtyard, Severn Drive GL20 8GD Tewkesbury Gloucestershire United Kingdom United Kingdom No longer Valid 4,4'-methylene bis(3-chloro-2,6-di-ethylphenylisocyanate) 420-530-1 - 2021 View substance registered dossier
DOW ITALIA S.R.L. Via F. Albani 65 20148 Milano Italy Italy Active 4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol 701-072-2 - 2019 View substance registered dossier
DOW DEUTSCHLAND ANLAGENGESELLSCHAFT mbH Am Kronberger Hang 4 D-65824 Schwalbach Germany Germany Active 4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol 701-072-2 - - View substance registered dossier
DOW BENELUX B.V. Postbus 48 4530 AA Terneuzen Netherlands Netherlands Active 4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol 701-072-2 - 2012; 2014; 2016; 2017; 2019 View substance registered dossier
BASF Espanola S.L. Calle Can Ràbia, n. 3-5 8017 Barcelona Spain Spain Cease Manufacture 4,4'-methylenediphenyldiisocyanate and 2,4'-diisocyanatodiphenylmethane and their oligomerisation reaction products with 2,2'-oxydiethanol, propane-1,2-diol and butane-1,3-diol 701-276-1 - 2020 View substance registered dossier
BASF Polyurethanes GmbH Elastogranstr. 60 49448 Lemförde Niedersachsen Germany Germany Cease Manufacture 4,4'-methylenediphenyldiisocyanate and 2,4'-diisocyanatodiphenylmethane and their oligomerisation reaction products with 2,2'-oxydiethanol, propane-1,2-diol and butane-1,3-diol 701-276-1 - 2020 View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active 4,4,19,19-tetraethoxy-3,20-dioxa-8,15-dithia-4,19-disiladocosaneand S-(6-{[3-(triethoxysilyl)propyl]thio}hexyl) ethanethioate 951-696-6 - - View substance registered dossier
[Confidential] - - - 4,4,19,19-tetraethoxy-3,20-dioxa-8,15-dithia-4,19-disiladocosaneand S-(6-{[3-(triethoxysilyl)propyl]thio}hexyl) ethanethioate 951-696-6 - - View substance registered dossier
Yordas GmbH Äußere Nürnberger Str. 62, 91301 Forchheim Germany Germany Active 4,4’-isopropylidenediphenol, reaction products with 1-chloro-2,3-epoxypropane, mono, di and triesters with acrylic acid 948-054-2 - 2019 View substance registered dossier
ARKEMA FRANCE 420 rue d'Estienne d'Orves 92700 COLOMBES France France Active 4,5-di-tert-butyl-6-ethoxy-2,2-dimethyl-3,7-dioxa-4-aza-6-phosphanonan-1-oic acid 6-oxide 449-920-8 - 2010 View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland Active 4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol 443-400-4 - 2016 View substance registered dossier
Piramal Healthcare UK Ltd Whalton Road NE61 3YA Morpeth Northumberland United Kingdom United Kingdom No longer Valid 4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol 443-400-4 - 2021 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol 443-400-4 - - View substance registered dossier
Fujifilm Imaging Colorants Limited Patricia Way Pysons Road Industrial Estate CT10 2LE Broadstairs Kent United Kingdom United Kingdom No longer Valid 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-(4-{2-[1,2,7,8-tetrahydro-7-(4-nitro-2-sulfophenylhydrazono)-1,8-dioxo-3,6-disulfo-2-naphthylidene]hydrazino}-3-sulfophenylhydrazono)pyrazole-3-carboxylic acid, lithium sodium salt 445-080-1 - 2021 View substance registered dossier
Fujifilm Europe GmbH (OR1) Heesenstr. 31 40549 Düsseldorf NRW Germany Germany Active 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-(4-{2-[1,2,7,8-tetrahydro-7-(4-nitro-2-sulfophenylhydrazono)-1,8-dioxo-3,6-disulfo-2-naphthylidene]hydrazino}-3-sulfophenylhydrazono)pyrazole-3-carboxylic acid, lithium sodium salt 445-080-1 - 2021 View substance registered dossier
ELIX Polymers, S.L. Poligono Industrial s/n Ctra. de Vilaseca - La Pineda 43006 Tarragona Spain Spain Active 4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate) 407-410-2 - 2016 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active 4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate) 407-410-2 - - View substance registered dossier
INEOS Styrolution Köln GmbH Alte Str. 201 50769 Köln NRW Germany Germany Active 4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate) 407-410-2 - 2011 View substance registered dossier
[Confidential] - - - 4-(1-((3-((2-(tert-butoxycarbonyl(methyl)amino)acetoxy)methyl)pyridin-2-yl)(methyl)carbamoyloxy)ethyl)-1-((2R,3S)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium)hemisulphate 926-418-1 - - View substance registered dossier
URQUIMA S.A. AVDA. CAMÍ REIAL, 51 -57 08184 PALAU-SOLITÀ I PLEGAMANS CATALUNYA Spain Spain Active 4-(2-aminoethyl)indole, fumarate 947-445-5 - - View substance registered dossier
FujiFilm Manufacturing Europe BV Oudenstaart 1 5047 TK Tilburg Netherlands Netherlands Cease Manufacture 4-(2-carboxymethylthio)ethoxy-1-hydroxy-5-isobutyloxycarbonylamino-N-(3-dodecyloxypropyl)-2-naphthamide 420-730-7 - 2019 View substance registered dossier
- - - - 4-(4'-Trifluoromethylphenyl)benzaldehyde 473-430-3 - - View substance registered dossier
Fine and Performance Chemicals Ltd Skutterskelfe TS15 0JR Hutton Rudby North Yorkshire United Kingdom United Kingdom No longer Valid 4-(4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-1-butynyl)-.alpha.,.alpha.-dimethylbenzeneacetic acid 462-560-6 - 2021 View substance registered dossier
DIPHARMA FRANCIS srl Bissone, 5 20021 Baranzate Milano Italy Italy Active 4-(4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-1-butynyl)-.alpha.,.alpha.-dimethylbenzeneacetic acid 462-560-6 - 2013; 2015 View substance registered dossier
Amino Chemicals Ltd Industrial Estate, A61 MRS3000 Marsa Malta Malta Active 4-(4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-1-butynyl)-.alpha.,.alpha.-dimethylbenzeneacetic acid 462-560-6 - - View substance registered dossier
TOYO INK EUROPE SPECIALTY CHEMICALS Boulevard Dambourney 76350 Oissel France France Active 4-(4-aminoanilino)-6-[3-(dibutylamino)propylamino]-heteromonocyclic-2-ol 427-670-0 - 2016 View substance registered dossier
- - - - 4-(4-aminoanilino)-6-[3-(dibutylamino)propylamino]-heteromonocyclic-2-ol 427-670-0 - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-(4-Brom-5-ethyl-tetrahydropyran-2-yl)-phenol 919-822-4 - - View substance registered dossier

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