Registered substances

Registered substances

Registered substances

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

Please note:
  • The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
  • Please be aware that the annual IUCLID format change is coming soon. We will be adapting the Dissemination platform to the new format, which means that as of 15th October 2021 until early 2022 there will be a break in publication of newly submitted registration dossiers. We appreciate your understanding in this matter.
Last updated 13 October 2021. Database contains 23445 unique substances and contains information from 104986 dossiers.
Substance identity
Administrative data
Submission type:
First published date:
Last update date:
Substance data
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Uses and exposure
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  • Consumer Uses
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  • Uses at industrial sites
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Details
(3S)-3,7-Dimethyl-1-octanol
814-059-2 68680-98-8 Active Full Joint ≥ 1 to < 10 tonnes 30-05-2018 View substance registered dossier
(3S)-3,7-dimethylocta-1,6-dien-1-yl acetate
946-529-9 1439355-19-7 Active Intermediate Joint Intermediate use only 24-01-2018 View substance registered dossier
(3S)-3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one
626-470-2 5405-40-3 Cease Manufacture Full Individual Cease manufacture 05-07-2011 View substance registered dossier
(3S)-3-hydroxypyrrolidin-2-one
676-349-3 34368-52-0 Active Intermediate Individual Intermediate use only 12-11-2019 View substance registered dossier
(3S)-3-thiophen-2-ylsulfanylbutanoic acid
948-811-7 133359-80-5 Active Intermediate Joint Intermediate use only 23-10-2018 View substance registered dossier
(3S)-3-{4-[8-(2,4-dichlorophenyl)-3-(methoxycarbonyl)-6,7-dihydro-5H-benzocyclohepten-9-yl]phenoxy}-1-(3-fluoropropyl)pyrrolidinium hydrogen oxalate
950-060-5 - Active Intermediate Joint Intermediate use only 15-01-2020 View substance registered dossier
(3S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine ethanedioate
603-567-8 132335-47-8 Active Intermediate Individual Intermediate use only 08-10-2009 View substance registered dossier
(3S, 4R)-4-(4’-Fluorophenyl)-3-(3’, 4’-methylenedioxyphenyl)-Nmethylpiperidine
924-787-3 110429-36-2 Active Intermediate Joint Intermediate use only 08-03-2021 View substance registered dossier
(3S,4aS,8aS)-2-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-tert-butyldecahydroisoquinoline-3-carboxamide
430-230-0 136522-17-3 Cease Manufacture NONS Individual Cease manufacture 13-09-2010 View substance registered dossier
(3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide
420-380-5 136465-81-1 Cease Manufacture Intermediate Individual Cease manufacture 29-10-2012 View substance registered dossier
(3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide
420-380-5 136465-81-1 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-1-benzyl-4-(4-fluorophenyl)piperidine
929-011-7 - Active Intermediate Joint Intermediate use only 20-04-2018 View substance registered dossier
(3S,4S)-3-hexyl-4-[(R)-2-hydroxytridecyl]-2-oxetanone
418-650-2 104872-06-2 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate
436-150-2 - Active Intermediate Joint Intermediate use only 16-05-2018 View substance registered dossier
(3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate
436-150-2 - Active Intermediate Joint Intermediate use only 12-07-2013 View substance registered dossier
(3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one
608-748-5 324763-46-4 Active Intermediate Joint Intermediate use only 13-08-2014 View substance registered dossier
(3S,5S,6S,9R)-6-isopropyl-3,9-dimethyl-1,4- and (3S,5R,6S,9R)-6-isopropyl-3,9-dimethyl-1,4-
457-410-1 831213-72-0 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol
450-320-3 - Active Full Joint ≥ 0 to < 10 tonnes 16-04-2018 View substance registered dossier
(3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol
450-320-3 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(3S,6E)-3,7,11-trimethyldodeca-6,10-dienal
810-298-1 194934-66-2 Active Full Joint ≥ 1 to < 10 tonnes 07-09-2020 View substance registered dossier
(3S,6R,9S,12R,15S,18R,21S,24R)-6,18-dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone
444-350-6 133413-70-4 Active Intermediate Joint Intermediate use only 24-09-2019 View substance registered dossier
(3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione
224-832-0 4511-42-6 Active Full Joint ≥ 1 000 to < 10 000 tonnes 26-07-2018 View substance registered dossier
(3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione
224-832-0 4511-42-6 Cease Manufacture Full Individual Cease manufacture 17-08-2015 View substance registered dossier
(3S-trans)-phenyl-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-piperidinecarboxylate
430-510-2 - Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(3Z)-hex-3-en-1-yl 2-methylprop-2-en-1-yl ether
439-790-0 292605-05-1 Active Full Individual ≥ 0 to < 10 tonnes 18-01-2013 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
TAKASAGO TEPL-OR(1) 12 rue Torricelli 75017 Paris France France Active (3S)-3,7-Dimethyl-1-octanol 814-059-2 68680-98-8 - View substance registered dossier
TAKASAGO TICSA-Producer/Importer Avenida de Mazarrón, 49 30120 El Palmar Murcia Spain Spain Active (3S)-3,7-dimethylocta-1,6-dien-1-yl acetate 946-529-9 1439355-19-7 - View substance registered dossier
TÜV SÜD Industrie Service GmbH IS-USR-MUC Westendstr. 199 80686 Munich Germany Germany Cease Manufacture (3S)-3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one 626-470-2 5405-40-3 2015 View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active (3S)-3-hydroxypyrrolidin-2-one 676-349-3 34368-52-0 - View substance registered dossier
DUKE CHEM, S.A. Avgda. Mare de Déu de Montserrat, 93 - 99 Pol. Ind. Sant Pere Molanta 08799 Olèrdola Barcelona Spain Spain Active (3S)-3-thiophen-2-ylsulfanylbutanoic acid 948-811-7 133359-80-5 - View substance registered dossier
sanofi chimie 82 avenue Raspail 94250 Gentilly France France Active (3S)-3-{4-[8-(2,4-dichlorophenyl)-3-(methoxycarbonyl)-6,7-dihydro-5H-benzocyclohepten-9-yl]phenoxy}-1-(3-fluoropropyl)pyrrolidinium hydrogen oxalate 950-060-5 - - View substance registered dossier
Saneca Pharmaceuticals a.s. Nitrianska 100 92027 Hlohovec Slovakia Slovakia Active (3S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine ethanedioate 603-567-8 132335-47-8 2009 View substance registered dossier
Thermofisher Scientific Cork Ltd. Currabinny P43 AY66 Carrigaline Co. Cork Ireland Ireland Active (3S, 4R)-4-(4’-Fluorophenyl)-3-(3’, 4’-methylenedioxyphenyl)-Nmethylpiperidine 924-787-3 110429-36-2 2021 View substance registered dossier
CHEMI S.p.A. Via dei lavoratori, 54 20092 Cinisello balsamo Lombardia Italy Italy Active (3S, 4R)-4-(4’-Fluorophenyl)-3-(3’, 4’-methylenedioxyphenyl)-Nmethylpiperidine 924-787-3 110429-36-2 - View substance registered dossier
Roche Ireland Limited Clarehill . Clarecastle Ireland Ireland Cease Manufacture (3S,4aS,8aS)-2-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-tert-butyldecahydroisoquinoline-3-carboxamide 430-230-0 136522-17-3 2020 View substance registered dossier
Roche Ireland Limited Clarehill . Clarecastle Ireland Ireland Cease Manufacture (3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide 420-380-5 136465-81-1 2020 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. - - Active (3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide 420-380-5 136465-81-1 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide 420-380-5 136465-81-1 - View substance registered dossier
Gedeon Richter Plc. Gyomroi ut 19-21 1103 Budapest Hungary Hungary Active (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-1-benzyl-4-(4-fluorophenyl)piperidine 929-011-7 - - View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Active (3S,4S)-3-hexyl-4-[(R)-2-hydroxytridecyl]-2-oxetanone 418-650-2 104872-06-2 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Austrian competent national authority. - - Active (3S,4S)-3-hexyl-4-[(R)-2-hydroxytridecyl]-2-oxetanone 418-650-2 104872-06-2 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (3S,4S)-3-hexyl-4-[(R)-2-hydroxytridecyl]-2-oxetanone 418-650-2 104872-06-2 - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Active (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - - View substance registered dossier
MSD International GmbH Ballydine - Kilsheelan 0 Clonmel Ireland Ireland Active (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - 2011; 2015 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - - View substance registered dossier
[Confidential] - - - (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - - View substance registered dossier
Novartis Integrated Services Limited Ringaskiddy P43 FR63 Ringaskiddy Co. Cork Ireland Ireland Active (3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one 608-748-5 324763-46-4 2014 View substance registered dossier
Novartis Grimsby Limited Moody Lane, Pyewipe DN31 2SR Grimsby N.E. Lincolnshire United Kingdom United Kingdom No longer Valid (3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one 608-748-5 324763-46-4 2021 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (3S,5S,6S,9R)-6-isopropyl-3,9-dimethyl-1,4- and (3S,5R,6S,9R)-6-isopropyl-3,9-dimethyl-1,4- 457-410-1 831213-72-0 - View substance registered dossier
- - - - (3S,5S,6S,9R)-6-isopropyl-3,9-dimethyl-1,4- and (3S,5R,6S,9R)-6-isopropyl-3,9-dimethyl-1,4- 457-410-1 831213-72-0 - View substance registered dossier
TAKASAGO TEPL-OR(1) 12 rue Torricelli 75017 Paris France France Active (3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol 450-320-3 - 2018 View substance registered dossier
- - - - (3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol 450-320-3 - - View substance registered dossier
TAKASAGO TEPL-Importer 12 rue Torricelli 75017 Paris France France Active (3S,6E)-3,7,11-trimethyldodeca-6,10-dienal 810-298-1 194934-66-2 2020 View substance registered dossier
TAKASAGO TEPL-OR(1) 12 rue Torricelli 75017 Paris France France Active (3S,6E)-3,7,11-trimethyldodeca-6,10-dienal 810-298-1 194934-66-2 - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active (3S,6R,9S,12R,15S,18R,21S,24R)-6,18-dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone 444-350-6 133413-70-4 2010; 2018 View substance registered dossier
Bayer Animal Health GmbH Alfred Nobel Straße 50 40789 Monheim Germany Germany Active (3S,6R,9S,12R,15S,18R,21S,24R)-6,18-dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone 444-350-6 133413-70-4 - View substance registered dossier
Total Corbion PLA bv Arkelsedijk 46 4206AC Gorinchem Netherlands Netherlands Active (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione 224-832-0 4511-42-6 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione 224-832-0 4511-42-6 - View substance registered dossier
PURAC Biochem Arkelsedijk 46 4206AC Gorinchem Netherlands Netherlands Active (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione 224-832-0 4511-42-6 2011; 2015 View substance registered dossier
Santrol Europe ApS Aagade 103 Pjedsted 7000 Fredericia Denmark Denmark Cease Manufacture (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione 224-832-0 4511-42-6 2016 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (3S-trans)-phenyl-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-piperidinecarboxylate 430-510-2 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (3S-trans)-phenyl-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-piperidinecarboxylate 430-510-2 - - View substance registered dossier
IFF Benicarlo, S.L. Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain Spain Active (3Z)-hex-3-en-1-yl 2-methylprop-2-en-1-yl ether 439-790-0 292605-05-1 2013 View substance registered dossier

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