Registered substances

Registered substances

Registered substances

Please note:

We have successfully adapted to the latest IUCLID format, and have resumed processing dossiers since 3 March 2022. Over the coming weeks we will catch up with the backlog of submissions since 14 October 2021, and expect to have all outstanding data online in approximately one month’s time. Please be aware that any new submissions will be at the back of the processing queue, and will be correspondingly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
tert-butyl bromoacetate
226-133-6 5292-43-3 Active Intermediate Joint Intermediate use only 22-01-2019 View substance registered dossier
tert-butyl acrylate
216-768-7 1663-39-4 Active Full Joint ≥ 1 tonnes 15-12-2020 View substance registered dossier
tert-butyl acetate
208-760-7 540-88-5 Active Full Joint ≥ 100 to < 1 000 tonnes 05-09-2016 View substance registered dossier
tert-butyl acetate
208-760-7 540-88-5 Active Intermediate Individual Intermediate use only 14-09-2020 View substance registered dossier
tert-Butyl [(1R,2S,5S)-2-[[2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl]amino]-5-(dimethylaminocarbonyl)cyclohexyl]carbamate
836-116-0 480452-36-6 Active Intermediate Joint Intermediate use only 09-10-2020 View substance registered dossier
tert-butyl 5'-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-carboxylate
848-454-6 1398610-04-2 Active Full Joint ≥ 1 to < 10 tonnes 28-02-2021 View substance registered dossier
tert-butyl 4-cyanopiperidine-1-carboxylate
624-826-1 91419-52-2 Active Intermediate Joint Intermediate use only 15-07-2021 View substance registered dossier
tert-butyl 4-[[(6-amino-5-chloro-pyrimidin-4-yl)amino]methyl]-4-fluoro-piperidine-1-carboxylate
954-331-9 - Active Intermediate Joint Intermediate use only 21-06-2021 View substance registered dossier
tert-butyl 4-[(E)-3-(dimethylamino)prop-2-enoyl]piperidine-1-carboxylate
859-135-6 1799799-87-3 Active Intermediate Individual Intermediate use only 27-10-2020 View substance registered dossier
TERT-BUTYL 4-({[6-AMINO-5-(4-PHENOXYPHENYL)PYRIMIDIN-4-YL]AMINO}METHYL)-4-FLUOROPIPERIDINE-1-CARBOXYLATE
941-339-2 - Active Intermediate Joint Intermediate use only 21-06-2021 View substance registered dossier
tert-Butyl 4-({6-[7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate
810-753-4 1374639-78-7 No longer Valid Full Individual No longer valid 27-08-2019 View substance registered dossier
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid
870-310-6 2368870-32-8 Active Intermediate Joint Intermediate use only 28-07-2021 View substance registered dossier
tert-butyl 3-oxobutanoate
216-904-5 1694-31-1 Active Full Joint ≥ 10 to < 100 tonnes 07-05-2018 View substance registered dossier
tert-butyl 3-oxobutanoate
216-904-5 1694-31-1 Active Intermediate Joint Intermediate use only 26-03-2018 View substance registered dossier
Tert-butyl 3-Cyano-4-oxo-pyrrolidine-1-carboxylate
700-004-9 175463-32-8 Active Intermediate Individual Intermediate use only 12-02-2009 View substance registered dossier
tert-butyl 3,5,5-trimethylperoxyhexanoate
236-050-7 13122-18-4 Active Full Joint ≥ 1 000 to < 10 000 tonnes 12-11-2020 View substance registered dossier
tert-butyl 2-oxopyrrolidine-1-carboxylate
617-776-7 85909-08-6 Active Intermediate Joint Intermediate use only 05-03-2020 View substance registered dossier
tert-butyl 2-hydroxyisobutyrate
252-952-3 36293-63-7 Active Intermediate Joint Intermediate use only 08-11-2017 View substance registered dossier
tert-butyl 2-ethylperoxyhexanoate
221-110-7 3006-82-4 Active Full Joint ≥ 1 000 to < 10 000 tonnes 16-08-2021 View substance registered dossier
tert-butyl 2-bromopropanoate
675-664-3 39149-80-9 Active Intermediate Joint Intermediate use only 24-04-2018 View substance registered dossier
Tert-butyl 2-[4-(2-pyridinyl) phenylmethyl] hydrazine carboxylate
429-080-9 - Active Full Joint ≥ 1 to < 10 tonnes 12-10-2017 View substance registered dossier
Tert-butyl 2-[4-(2-pyridinyl) phenylmethyl] hydrazine carboxylate
429-080-9 - Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
tert-butyl 2-[(2S,3S)-2-(benzyloxy)pentan-3-yl]hydrazinecarboxylate
606-022-2 184177-88-6 Active Intermediate Individual Intermediate use only 30-05-2018 View substance registered dossier
tert-butyl (triphenylphosphoranylidene) acetate
1,1-DIMETHYLETHOXY-CARBONYL-METHYLEN-TRIPHENYLPHOSPHORAN; DMY; PHOSPHORANE
412-880-7 35000-38-5 Active NONS Joint Tonnage data confidential 14-07-2011 View substance registered dossier
tert-butyl (S)-2-carbamoylpyrrolidine-1-carboxylate
626-262-1 35150-07-3 Active Intermediate Joint Intermediate use only 28-11-2017 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
PALCHEM Rue du Transvaal BP22 62143 ANGRES France France Active tert-butyl bromoacetate 226-133-6 5292-43-3 - View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active tert-butyl bromoacetate 226-133-6 5292-43-3 - View substance registered dossier
Biesterfeld Spezialchemie GmbH Ferdinandstr. 41 20095 Hamburg Germany Germany Active tert-butyl bromoacetate 226-133-6 5292-43-3 - View substance registered dossier
Intertek Italia SpA_ITAzo Via Miglioli 2/A 20063 CERNUSCO SUL NAVIGLIO Milano Italy Italy Active tert-butyl bromoacetate 226-133-6 5292-43-3 - View substance registered dossier
B-Lands Consulting (811725-2) 5 Place Robert Schuman - BP 1516 38025 Grenoble France France France Active tert-butyl bromoacetate 226-133-6 5292-43-3 - View substance registered dossier
Chemreach GmbH Akazienweg 30 48317 Drensteinfurt Germany Germany Active tert-butyl acrylate 216-768-7 1663-39-4 - View substance registered dossier
Du Pont de Nemours (Deutschland) GmbH Hugenottenallee 175 D-63263 Neu-Isenburg Hesse Germany Germany Active tert-butyl acrylate 216-768-7 1663-39-4 - View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Active tert-butyl acrylate 216-768-7 1663-39-4 2012; 2014; 2017 View substance registered dossier
Axalta Coating Systems Germany GmbH & Co. KG Christbusch 25 42285 Wuppertal Germany Germany Active tert-butyl acrylate 216-768-7 1663-39-4 - View substance registered dossier
Lyondell Chemie Nederland B.V. Deltseplein 27E 3013 AA Rotterdam Netherlands Netherlands Active tert-butyl acetate 208-760-7 540-88-5 2013; 2014; 2015; 2016 View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active tert-butyl acetate 208-760-7 540-88-5 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active tert-Butyl [(1R,2S,5S)-2-[[2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl]amino]-5-(dimethylaminocarbonyl)cyclohexyl]carbamate 836-116-0 480452-36-6 - View substance registered dossier
Zoetis Belgium S.A. Rue Laid Burniat, 1 1348 Louvain-La-Neuve Belgium Belgium Active tert-butyl 5'-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-carboxylate 848-454-6 1398610-04-2 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active tert-butyl 4-cyanopiperidine-1-carboxylate 624-826-1 91419-52-2 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active tert-butyl 4-[[(6-amino-5-chloro-pyrimidin-4-yl)amino]methyl]-4-fluoro-piperidine-1-carboxylate 954-331-9 - - View substance registered dossier
Siegfried St. Vulbas SAS 530, allée de la Luye 01150 SAINT VULBAS France France Active tert-butyl 4-[(E)-3-(dimethylamino)prop-2-enoyl]piperidine-1-carboxylate 859-135-6 1799799-87-3 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active TERT-BUTYL 4-({[6-AMINO-5-(4-PHENOXYPHENYL)PYRIMIDIN-4-YL]AMINO}METHYL)-4-FLUOROPIPERIDINE-1-CARBOXYLATE 941-339-2 - - View substance registered dossier
Novartis Grimsby Limited Moody Lane, Pyewipe DN31 2SR Grimsby N.E. Lincolnshire United Kingdom United Kingdom No longer Valid tert-Butyl 4-({6-[7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate 810-753-4 1374639-78-7 2021 View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active tert-butyl 4-(aminomethyl)piperidine-1-carboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid 870-310-6 2368870-32-8 - View substance registered dossier
Valtris Specialty Chemicals Ltd Lankro Way PO Box 1 , Eccles M30 OLX Manchester Greater Manchester United Kingdom United Kingdom No longer Valid tert-butyl 3-oxobutanoate 216-904-5 1694-31-1 2021 View substance registered dossier
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden Sweden Active tert-butyl 3-oxobutanoate 216-904-5 1694-31-1 2018 View substance registered dossier
YOU Solutions Germany GmbH - REACH (part of Arxada) Nattermannallee 1 50829 Cologne Germany Germany Active tert-butyl 3-oxobutanoate 216-904-5 1694-31-1 2017 View substance registered dossier
Eastman Chemical B.V. Watermanweg 70 3067 GG Rotterdam Netherlands Netherlands Active tert-butyl 3-oxobutanoate 216-904-5 1694-31-1 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active tert-butyl 3-oxobutanoate 216-904-5 1694-31-1 - View substance registered dossier
PROCOS SpA via Matteotti 249 28062 Cameri Piemonte Italy Italy Active Tert-butyl 3-Cyano-4-oxo-pyrrolidine-1-carboxylate 700-004-9 175463-32-8 - View substance registered dossier
Nouryon Chemicals NV/SA Parc Industriel de Ghlin Zone A 7011 Ghlin Mons Belgium Belgium Active tert-butyl 3,5,5-trimethylperoxyhexanoate 236-050-7 13122-18-4 2012; 2014; 2017; 2019 View substance registered dossier
3M Belgium BVBA/SPRL Hermeslaan 7 1831 Diegem Belgium Belgium Active tert-butyl 3,5,5-trimethylperoxyhexanoate 236-050-7 13122-18-4 - View substance registered dossier
PERGAN GmbH Schlavenhorst 71 46395 Bocholt NRW Germany Germany Active tert-butyl 3,5,5-trimethylperoxyhexanoate 236-050-7 13122-18-4 2017 View substance registered dossier
United Initiators GmbH Dr. Gustav-Adolph-Str. 3 D-82049 Pullach Bavaria Germany Germany Active tert-butyl 3,5,5-trimethylperoxyhexanoate 236-050-7 13122-18-4 2011; 2014; 2017; 2020 View substance registered dossier
ARKEMA Gmbh Tersteegenstrasse 28 40401 Düsseldorf Germany Germany Active tert-butyl 3,5,5-trimethylperoxyhexanoate 236-050-7 13122-18-4 2016; 2017 View substance registered dossier
Perga-Chem GmbH Vor dem Gröperntor 20 06484 Quedlinburg Germany Germany Active tert-butyl 3,5,5-trimethylperoxyhexanoate 236-050-7 13122-18-4 2017 View substance registered dossier
REACH GLOBAL SERVICES S.A Rond Point Schuman, 6 B-1040 Brussels Belgium Belgium Active tert-butyl 3,5,5-trimethylperoxyhexanoate 236-050-7 13122-18-4 - View substance registered dossier
Chr. Olesen ChemPharm GmbH Gustav-Becker-Strasse 20B 21218 Seevetal Germany Germany Active tert-butyl 2-oxopyrrolidine-1-carboxylate 617-776-7 85909-08-6 - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Active tert-butyl 2-oxopyrrolidine-1-carboxylate 617-776-7 85909-08-6 2020 View substance registered dossier
PCAS 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France France Active tert-butyl 2-hydroxyisobutyrate 252-952-3 36293-63-7 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 - View substance registered dossier
Valspar b.v. Zuiveringweg 89 8243 PE Lelystad Netherlands Netherlands Active tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 2020 View substance registered dossier
ARKEMA Gmbh Tersteegenstrasse 28 40401 Düsseldorf Germany Germany Active tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 2016; 2017; 2019 View substance registered dossier
United Initiators GmbH Dr. Gustav-Adolph-Str. 3 D-82049 Pullach Bavaria Germany Germany Active tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 2011; 2014; 2016; 2019; 2020 View substance registered dossier
PERGAN GmbH Schlavenhorst 71 46395 Bocholt NRW Germany Germany Active tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 2016 View substance registered dossier
3M Belgium BVBA/SPRL Hermeslaan 7 1831 Diegem Belgium Belgium Active tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 - View substance registered dossier
SCAS Europe S.A./N.V. Leonardo Da Vincilaan 19 B-1831 Diegem Belgium Belgium Active tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 - View substance registered dossier
Nouryon Chemicals NV/SA Parc Industriel de Ghlin Zone A 7011 Ghlin Mons Belgium Belgium Active tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 2012; 2013; 2017; 2019 View substance registered dossier
Perga-Chem GmbH Vor dem Gröperntor 20 06484 Quedlinburg Germany Germany Active tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 2013; 2017 View substance registered dossier
Axalta Coating Systems Germany GmbH & Co. KG Christbusch 25 42285 Wuppertal Germany Germany Active tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 - View substance registered dossier
DIPHARMA FRANCIS srl Bissone, 5 20021 Baranzate Milano Italy Italy Active tert-butyl 2-bromopropanoate 675-664-3 39149-80-9 - View substance registered dossier
TSE, OR for Tosoh Finechem Rembrandt Tower Amstelplein 1 1096 HA Amsterdam Netherlands Netherlands Active tert-butyl 2-bromopropanoate 675-664-3 39149-80-9 - View substance registered dossier
B-Lands Consulting (811725-2) 5 Place Robert Schuman - BP 1516 38025 Grenoble France France France Active tert-butyl 2-bromopropanoate 675-664-3 39149-80-9 - View substance registered dossier
Swords Laboratories Unlimited Company Cruiserath Road Mulhuddart D15H6EF Dublin 15 Co Dublin Ireland Ireland Active Tert-butyl 2-[4-(2-pyridinyl) phenylmethyl] hydrazine carboxylate 429-080-9 - 2010; 2017 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. - - Active Tert-butyl 2-[4-(2-pyridinyl) phenylmethyl] hydrazine carboxylate 429-080-9 - - View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active Tert-butyl 2-[4-(2-pyridinyl) phenylmethyl] hydrazine carboxylate 429-080-9 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active Tert-butyl 2-[4-(2-pyridinyl) phenylmethyl] hydrazine carboxylate 429-080-9 - - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Active tert-butyl 2-[(2S,3S)-2-(benzyloxy)pentan-3-yl]hydrazinecarboxylate 606-022-2 184177-88-6 - View substance registered dossier
Glaxo Operations UK Glaxo Wellcome House Berkeley Avenue UB6 0NN Greenford Middlesex United Kingdom United Kingdom No longer Valid tert-butyl (triphenylphosphoranylidene) acetate 412-880-7 35000-38-5 2021 View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active tert-butyl (triphenylphosphoranylidene) acetate 412-880-7 35000-38-5 2011 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active tert-butyl (triphenylphosphoranylidene) acetate 412-880-7 35000-38-5 - View substance registered dossier
[Confidential] - - - tert-butyl (S)-2-carbamoylpyrrolidine-1-carboxylate 626-262-1 35150-07-3 - View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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