Registered substances

Registered substances

Registered substances

Please note:

We have successfully adapted to the latest IUCLID format, and have resumed processing dossiers since 3 March 2022. Over the coming weeks we will catch up with the backlog of submissions since 14 October 2021, and expect to have all outstanding data online in approximately one month’s time. Please be aware that any new submissions will be at the back of the processing queue, and will be correspondingly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



No results were found
Details
Tosilato
- - Active Intermediate Joint Intermediate use only 24-05-2022 View substance registered dossier
Tosyl chloride
202-684-8 98-59-9 Active Intermediate Joint Intermediate use only 14-01-2022 View substance registered dossier
Tramadol
248-319-6 27203-92-5 Active Intermediate Joint Intermediate use only 29-05-2018 View substance registered dossier
Trans 2,6,6-trimethyl-3-cyclohexen-1-yl]trichloroethanone
918-495-5 - Active Intermediate Individual Intermediate use only 20-04-2018 View substance registered dossier
trans,trans-4-((Z)-Propen-1-yl)-4'-propyl-bicyclohexan
922-166-1 - Active Intermediate Joint Intermediate use only 01-04-2021 View substance registered dossier
trans-(4S,6S)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol, 7,7-dioxide
FC4010
417-290-3 147086-81-5 Active Intermediate Individual Intermediate use only 27-10-2010 View substance registered dossier
trans-(5RS,6SR)-6-amino-2,2-dimethyl-1,3-dioxepan-5-ol
AMINODIOXEPAN
419-050-3 79944-37-9 Active Intermediate Individual Intermediate use only 18-11-2010 View substance registered dossier
Trans-2,6-dimethylindan-1-amine
700-575-4 1351564-23-2 Active Intermediate Individual Intermediate use only 23-09-2011 View substance registered dossier
trans-2-(4-Bromophenyl)-5-propyltetrahydro-2H-pyran
- - Active Intermediate Joint Intermediate use only 07-03-2022 View substance registered dossier
trans-2-isopropyl-5-carboxy-1,3-dioxane
DHP OPT
445-770-2 42031-28-7 Active Intermediate Joint Intermediate use only 28-11-2014 View substance registered dossier
trans-2-isopropyl-5-carboxy-1,3-dioxane
DHP OPT
445-770-2 42031-28-7 Active Intermediate Individual Intermediate use only 11-11-2011 View substance registered dossier
trans-3,4-(methylenedioxy)cinnamic acid
219-151-0 2373-80-0 Active Intermediate Joint Intermediate use only 21-11-2016 View substance registered dossier
trans-4-(tetrahydro-5-propyl-pyran-2-yl)-phenol
937-897-1 - Active Intermediate Joint Intermediate use only 19-02-2018 View substance registered dossier
trans-4-(trans-4-(4-Methylphenyl)-cyclohexyl)-cyclohexancarbaldehyde
605-043-4 156140-04-4 Active Intermediate Joint Intermediate use only 16-07-2019 View substance registered dossier
trans-4-[[(2-Amino-3,5-dibromophenyl)methylene]amino]cyclohexanol
641-602-9 50910-53-7 Active Intermediate Individual Intermediate use only 13-04-2018 View substance registered dossier
trans-4-aminocyclohexan-1-ol
248-492-8 27489-62-9 Active Intermediate Joint Intermediate use only 23-01-2018 View substance registered dossier
trans-4-aminocyclohexan-1-ol
248-492-8 27489-62-9 Active Intermediate Individual Intermediate use only 09-03-2012 View substance registered dossier
trans-4-cyclohexyl-L-proline monohydrochloride
SQ28,646
419-160-1 90657-55-9 Active Intermediate Joint Intermediate use only 30-07-2015 View substance registered dossier
trans-4-methoxycinnamic acid
212-594-0 830-09-1 Active Intermediate Joint Intermediate use only 26-04-2018 View substance registered dossier
trans-4-Methylcyclohexyl isocyanate
608-715-5 32175-00-1 Active Intermediate Joint Intermediate use only 15-05-2018 View substance registered dossier
trans-4-phenyl-L-proline
SQ 27,616
416-020-1 96314-26-0 Active Intermediate Individual Intermediate use only 13-04-2017 View substance registered dossier
trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexanamine dihydrochloride
919-579-4 - Active Intermediate Individual Intermediate use only 28-02-2022 View substance registered dossier
trans-cinnamic acid
205-398-1 140-10-3 Active Intermediate Joint Intermediate use only 19-11-2021 View substance registered dossier
trans-cinnamic acid
205-398-1 140-10-3 Active Intermediate Individual Intermediate use only 31-03-2016 View substance registered dossier
trans-decahydro-2-naphthol
212-545-3 825-51-4 Active Intermediate Joint Intermediate use only 13-08-2019 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
ICROM S.r.l Via delle arti, 33 20863 Concorezzo Italy Italy Active Tosilato - - - View substance registered dossier
ARCHROMA IBÉRICA, S.L. ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain Spain Active Tosyl chloride 202-684-8 98-59-9 - View substance registered dossier
Chr. Olesen ChemPharm GmbH Gustav-Becker-Strasse 20B 21218 Seevetal Germany Germany Active Tosyl chloride 202-684-8 98-59-9 - View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active Tosyl chloride 202-684-8 98-59-9 2017 View substance registered dossier
ACETO GmbH Hans-Henny-Jahnn-Weg 53 22085 Hamburg Germany Germany Active Tosyl chloride 202-684-8 98-59-9 - View substance registered dossier
Esteve Quimica, S.A. Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain Spain Active Tosyl chloride 202-684-8 98-59-9 - View substance registered dossier
ABCR GmbH Im Schlehert 10 76187 Karlsruhe Germany Germany Active Tosyl chloride 202-684-8 98-59-9 - View substance registered dossier
SONEAS Chemicals Ltd. Banyaleg Str. 47-59. H-1225 Budapest Hungary Hungary Active Tosyl chloride 202-684-8 98-59-9 - View substance registered dossier
sanofi chimie 82 avenue Raspail 94250 Gentilly France France Active Tosyl chloride 202-684-8 98-59-9 - View substance registered dossier
Saneca Pharmaceuticals a.s. Nitrianska 100 92027 Hlohovec Slovakia Slovakia Active Tramadol 248-319-6 27203-92-5 - View substance registered dossier
DIPHARMA FRANCIS srl Bissone, 5 20021 Baranzate Milano Italy Italy Active Tramadol 248-319-6 27203-92-5 - View substance registered dossier
LA MESTA CHIMIE FINE 1336 Route de l'Estéron 06830 GILETTE France France Active Trans 2,6,6-trimethyl-3-cyclohexen-1-yl]trichloroethanone 918-495-5 - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active trans,trans-4-((Z)-Propen-1-yl)-4'-propyl-bicyclohexan 922-166-1 - 2021 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active trans-(4S,6S)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol, 7,7-dioxide 417-290-3 147086-81-5 - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active trans-(5RS,6SR)-6-amino-2,2-dimethyl-1,3-dioxepan-5-ol 419-050-3 79944-37-9 2010 View substance registered dossier
Saltigo GmbH HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany Germany Active Trans-2,6-dimethylindan-1-amine 700-575-4 1351564-23-2 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active trans-2-(4-Bromophenyl)-5-propyltetrahydro-2H-pyran - - - View substance registered dossier
guerbet BP57400 95743 roissy cdg cedex France France Active trans-2-isopropyl-5-carboxy-1,3-dioxane 445-770-2 42031-28-7 - View substance registered dossier
[Confidential] - - - trans-2-isopropyl-5-carboxy-1,3-dioxane 445-770-2 42031-28-7 - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active trans-3,4-(methylenedioxy)cinnamic acid 219-151-0 2373-80-0 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active trans-4-(tetrahydro-5-propyl-pyran-2-yl)-phenol 937-897-1 - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active trans-4-(trans-4-(4-Methylphenyl)-cyclohexyl)-cyclohexancarbaldehyde 605-043-4 156140-04-4 2019 View substance registered dossier
A.M.S.A. Anonima Materie Sintetiche e Affini S.p.A. Viale del Ghisallo, 20 20151 Milano Italy Italy Active trans-4-[[(2-Amino-3,5-dibromophenyl)methylene]amino]cyclohexanol 641-602-9 50910-53-7 - View substance registered dossier
ERREGIERRE SPA Via Francesco Baracca, 19 24060 SAN PAOLO D'ARGON BERGAMO Italy Italy Active trans-4-aminocyclohexan-1-ol 248-492-8 27489-62-9 - View substance registered dossier
LA FENICE TRADING SRL VIA BERGAMO 18 20900 MONZA (MILANO) LOMBARDIA Italy Italy Cease Manufacture trans-4-aminocyclohexan-1-ol 248-492-8 27489-62-9 2019 View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Active trans-4-aminocyclohexan-1-ol 248-492-8 27489-62-9 2017 View substance registered dossier
Cambrex Profarmaco Milano Srl via Curiel, 34 20067 Paullo MI Italy Italy Active trans-4-aminocyclohexan-1-ol 248-492-8 27489-62-9 - View substance registered dossier
AGC Pharma Chemicals Europe, S.L.U. Camí de la Pomereda, 13 08380 Malgrat de Mar (Barcelona) Spain Spain Active trans-4-aminocyclohexan-1-ol 248-492-8 27489-62-9 2016 View substance registered dossier
A.M.S.A. Anonima Materie Sintetiche e Affini S.p.A. Viale del Ghisallo, 20 20151 Milano Italy Italy Active trans-4-aminocyclohexan-1-ol 248-492-8 27489-62-9 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active trans-4-cyclohexyl-L-proline monohydrochloride 419-160-1 90657-55-9 - View substance registered dossier
L.C.M. TRADING SPA via Mazzini 33 20099 Sesto San Giovanni Lombardia Italy Italy Active trans-4-cyclohexyl-L-proline monohydrochloride 419-160-1 90657-55-9 2013 View substance registered dossier
Swords Laboratories Cruiserath Road Mulhuddart D15H6EF Dublin 15 Co Dublin Ireland Ireland Active trans-4-cyclohexyl-L-proline monohydrochloride 419-160-1 90657-55-9 2010; 2015 View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active trans-4-methoxycinnamic acid 212-594-0 830-09-1 - View substance registered dossier
Croda EU B.V. (OR1) Buurtje 1 2802 BE Gouda Netherlands Netherlands Active trans-4-methoxycinnamic acid 212-594-0 830-09-1 - View substance registered dossier
Sanofi Aventis Deutschland GmbH Industriepark Höchst H 831 (Room A0472) z.Hd. Hr. Dr. Schwind 65926 Frankfurt am Main Germany Germany Active trans-4-Methylcyclohexyl isocyanate 608-715-5 32175-00-1 - View substance registered dossier
Siegfried St. Vulbas SAS 530, allée de la Luye 01150 SAINT VULBAS France France Active trans-4-phenyl-L-proline 416-020-1 96314-26-0 - View substance registered dossier
Gedeon Richter Plc. Gyomroi ut 19-21 1103 Budapest Hungary Hungary Active trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexanamine dihydrochloride 919-579-4 - - View substance registered dossier
Biesterfeld Spezialchemie GmbH Ferdinandstr. 41 20095 Hamburg Germany Germany Active trans-cinnamic acid 205-398-1 140-10-3 2018; 2020 View substance registered dossier
Upjohn Manufacturing Ireland Unlimited Little Island T45 F627 Co. Cork Ireland Ireland Active trans-cinnamic acid 205-398-1 140-10-3 2021 View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active trans-cinnamic acid 205-398-1 140-10-3 - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active trans-decahydro-2-naphthol 212-545-3 825-51-4 2019 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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