Registered substances

Registered substances

Registered substances

Please note:

As of end June 2022 we have processed and published all dossiers that had been pending since 14 October 2021. While daily processing has resumed there remains a processing queue. New submissions will be at the back of the processing queue, and may be slightly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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(R)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol
929-946-0 - Active Intermediate Joint Intermediate use only 05-12-2017 View substance registered dossier
(R)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol (R)-acetoxy(phenyl)acetate
929-947-6 - Active Intermediate Joint Intermediate use only 31-10-2017 View substance registered dossier
(R)-2-acetamido-3-naphthyl-2-yl-propionic acid
(R)-2-ACETAMIDO-3-NAPHTHYLEN-2-YL-PROPIONIC ACID
440-450-9 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(R)-2-dimethylamino-4-imino-6-methyl-1,4,5,6-tetrahydro-1,3,5-triazine, L-tartrate
942-402-7 - Active Intermediate Joint Intermediate use only 24-09-2021 View substance registered dossier
(R)-3-(1-methyl-2-pyrrolidinylmethyl)-5-[2-(phenylsulphonyl)ethyl]-1H-indole
921-685-0 - Active Intermediate Joint Intermediate use only 05-08-2022 View substance registered dossier
(R)-4-(4-dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hemi (2R, 3R)-2,3-bis((4-methylbenzoyl)oxy)succinoate
949-784-4 - Active Intermediate Individual Intermediate use only 25-03-2019 View substance registered dossier
(R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide (7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate
920-209-9 - Active Intermediate Joint Intermediate use only 30-05-2018 View substance registered dossier
(S) (2Z,4E)-4-carboxy-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid disodium salt
918-890-2 - Active Intermediate Joint Intermediate use only 23-03-2018 View substance registered dossier
(S)-(-)-tetrahydro-2-furoic acid
433-770-5 - No longer Valid Intermediate Individual No longer valid 22-09-2011 View substance registered dossier
(S)-(-)-tetrahydro-2-furoic acid
433-770-5 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(S)-1’- (tert-butyl)-2’-oxo-1’,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxylic acid
- - Active Intermediate Joint Intermediate use only 30-03-2022 View substance registered dossier
(S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]-bipyridine]-3-carboxylic acid
- - Active Intermediate Joint Intermediate use only 06-07-2022 View substance registered dossier
(S)-2-(1-aminopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one hydrochloride
942-180-1 - Cease Manufacture Intermediate Individual Cease manufacture 28-08-2015 View substance registered dossier
(S)-2-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoic acid
951-381-3 - Active Intermediate Individual Intermediate use only 02-07-2021 View substance registered dossier
(S)-2-(5-Methylheteromonocycle-2-carboxamido)-alkenoic acid
- - Active Intermediate Joint Intermediate use only 09-10-2013 View substance registered dossier
(S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one
480-320-9 - Active Full Joint ≥ 0 tonnes 06-02-2009 View substance registered dossier
(S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one
480-320-9 - Active Intermediate Joint Intermediate use only 10-07-2019 View substance registered dossier
(S)-5-chloro-4-methyl-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole dihydrochloride
948-271-2 - Active Intermediate Joint Intermediate use only 09-07-2018 View substance registered dossier
(S)-7-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one glucopyranosyl ether
471-940-0 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(S)-[2-(phenylmethoxy)propylidene]hydrazinecarboxylate, tert-butyle
439-220-0 - Active Intermediate Joint Intermediate use only 08-07-2015 View substance registered dossier
(S)-[2-(phenylmethoxy)propylidene]hydrazinecarboxylate, tert-butyle
439-220-0 - Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
(S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate
445-820-3 - Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
(S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate
445-820-3 - Active Intermediate Individual Intermediate use only 19-06-2018 View substance registered dossier
(S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-amine
942-077-1 - Active Intermediate Joint Intermediate use only 18-01-2018 View substance registered dossier
(S)-propane-1,2-diamine bis((2S,3S)-2,3-dihydroxysuccinate) dihydrate
924-425-4 - Active Intermediate Joint Intermediate use only 07-08-2020 View substance registered dossier
(S)-tert-butyl(1-((3-fluoro-2-(phenylcarbamoyl)phenyl)amino)-1-oxobutan-2 yl)carbamate
942-159-7 - Cease Manufacture Intermediate Individual Cease manufacture 20-07-2015 View substance registered dossier
(S)-tert.-Butyl-[2-(aminoethoxy)-[1,2]oxaborolan-4-yl]acetate
942-682-0 - Active Intermediate Individual Intermediate use only 05-03-2018 View substance registered dossier
(S)Ammonium-(2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
926-381-1 - Active Intermediate Joint Intermediate use only 23-03-2018 View substance registered dossier
(Trimethoxysilyl)methyl 2-methacrylate
454-220-0 - Active Full Joint ≥ 10 tonnes 16-11-2016 View substance registered dossier
(xylenes and 4-ethylbenzene)sulfonic acids
701-247-3 - Active Full Joint ≥ 1 000 to < 10 000 tonnes 01-09-2022 View substance registered dossier
(Z)-3-(chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide
953-723-7 - Active Intermediate Joint Intermediate use only 22-02-2021 View substance registered dossier
(Z)-but-2-enedioic acid;N-[2-(dimethylamino)ethyl]-5-(dithiolan-3-yl)pentanamide
922-363-2 - Active Full Individual ≥ 0 to < 10 tonnes 26-09-2019 View substance registered dossier
1,1'-(dodecylimino)dipropan-2-ol + 1,1'-(tetradecylimino)dipropan-2-ol
911-174-0 - Active Intermediate Joint Intermediate use only 30-01-2013 View substance registered dossier
1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea)
416-600-4 - Active Full Joint Tonnage data confidential 04-05-2011 View substance registered dossier
1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea)
416-600-4 - Active Full Joint ≥ 1 000 tonnes 25-08-2021 View substance registered dossier
1,1'-[propane-1,3-diylbis(oxy)]bis(2-bromo-4-tert-butylbenzene)
925-064-5 - Active Intermediate Individual Intermediate use only 23-04-2019 View substance registered dossier
1,1'-Biphenyl, 4'-butyl-3-fluoro-
935-978-6 - Active Intermediate Joint Intermediate use only 13-12-2017 View substance registered dossier
1,1'-bis(diphenylphosphino) ferrocene
1,1'-BIS(DIPHENYLPHOSPHINO) FERROCENE
430-420-3 - Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
1,1'-Methylenebis(4-isocyanatobenzene) and 1,1'-methylenebis(4-isocyanatobenzene) homopolymer and their reaction products with [(methylethylene)bis(oxy)]dipropanol and butane-1,3-diol and propane-1,2-diol
701-393-8 - Active Full Joint ≥ 100 000 to < 1 000 000 tonnes 27-10-2021 View substance registered dossier
1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol
701-124-4 - Active Full Joint ≥ 10 000 to < 100 000 tonnes 18-08-2022 View substance registered dossier
1,1'-methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with butane-1,3-diol, 2,2'-oxydiethanol and propane-1,2-diol
701-173-1 - Active Full Joint ≥ 100 000 to < 1 000 000 tonnes 22-10-2021 View substance registered dossier
1,1'-Methylenebis(4-isocyanatobenzene) and oligomeric reaction products of 1,1'-methylenebis(4-isocyanatobenzene) and oxydipropanol and oligomerization reaction products of oxydipropanol
701-041-3 - Active Full Joint ≥ 10 000 to < 100 000 tonnes 21-10-2021 View substance registered dossier
1,1'-{(phenylmethanediyl)bis[(3-substituted benzene-4,1-diyl)diazene-2,1-diyl{1-[3-(dimethylamino)propyl]-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridine-5,3-diyl}]}dipyridinium chloride lactate salts
700-136-7 - Active Full Individual ≥ 1 to < 10 tonnes 06-03-2013 View substance registered dossier
1,1'-{2-(2,4-difluorophenyl)-2-[(trimethylsilyl)oxy]propane-1,3-diyl}bis(1H-1,2,4-triazole)
928-141-1 - Active Intermediate Joint Intermediate use only 10-12-2021 View substance registered dossier
1,1,1"((methylsilanetriyl)tris)(oxy))tris(2-methylpropan-2-amine)
- - Active Full Joint ≥ 0 to < 10 tonnes 05-07-2022 View substance registered dossier
1,1,1,2,3,3-hexafluoro-3-methoxy-2-(trifluoromethyl)propane
422-270-2 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
1,1,1,2,3,3-hexafluoro-3-methoxy-2-(trifluoromethyl)propane
422-270-2 - Active Full Joint ≥ 10 tonnes 08-06-2022 View substance registered dossier
1,1,1,2,3,3-hexafluoro-4-(1,1,2,3,3,3-hexafluoropropoxy)pentane
484-290-8 - Active NONS Individual Tonnage data confidential 15-03-2011 View substance registered dossier
1,1,1-tris(phenyl-4'-(6''-diazo-5'',6''-dihydro-5''-oxo-naphthalene-1''-sulfonato)ethane;reaction mass of: 1,1,1-tris(phenyl-4'-(3''-diazo-3'',4''-dihydro-4''-oxo-naphthalene-1''-sulfonato)ethane;reaction product of 1,1,1-tris(p-hydroxyphenyl)ethane with 6-diazo-5,6-dihydro-5-oxo-1-naphthylsulfonylchloride and 3-diazo-3,4-dihydro-4-oxo-1-naphthylsulfonylchloride (1:2);reaction product of 1,1,1-tris(p-hydroxyphenyl)ethane with 6-diazo-5,6-dihydro-5-oxo-1-naphthylsulfonylchloride and 3-diazo-3,4-dihydro-4-oxo-1-naphthylsulfonylchloride (2:1)
422-760-6 - Cease Manufacture NONS Individual Cease manufacture 07-02-2011 View substance registered dossier
1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(2-hydroxyethyl)-1-butanesulfonamide
454-680-2 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (R)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol 929-946-0 - - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (R)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol (R)-acetoxy(phenyl)acetate 929-947-6 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (R)-2-acetamido-3-naphthyl-2-yl-propionic acid 440-450-9 - - View substance registered dossier
PCAS 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France France Active (R)-2-dimethylamino-4-imino-6-methyl-1,4,5,6-tetrahydro-1,3,5-triazine, L-tartrate 942-402-7 - 2018; 2021 View substance registered dossier
PCAS 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France France No longer Valid (R)-2-dimethylamino-4-imino-6-methyl-1,4,5,6-tetrahydro-1,3,5-triazine, L-tartrate 942-402-7 - - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (R)-3-(1-methyl-2-pyrrolidinylmethyl)-5-[2-(phenylsulphonyl)ethyl]-1H-indole 921-685-0 - - View substance registered dossier
Upjohn Manufacturing Ireland Unlimited Little Island T45 F627 Co. Cork Ireland Ireland Active (R)-3-(1-methyl-2-pyrrolidinylmethyl)-5-[2-(phenylsulphonyl)ethyl]-1H-indole 921-685-0 - - View substance registered dossier
Lundbeck Pharmaceuticals Italy S.p.A via quarta strada 2 35129 padova Italy Italy Active (R)-4-(4-dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hemi (2R, 3R)-2,3-bis((4-methylbenzoyl)oxy)succinoate 949-784-4 - - View substance registered dossier
Synthon, s.r.o. Brněnská 32 678 01 Blansko Czech Republic Czech Republic Active (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide (7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate 920-209-9 - - View substance registered dossier
Bábolna Bioenvironmental Centre Ltd. Szállás u. 6. H-1107 Budapest Hungary Hungary Active (S) (2Z,4E)-4-carboxy-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid disodium salt 918-890-2 - - View substance registered dossier
Carbogen Amcis Ltd 303 Clayton Lane M11 4SX Manchester Greater Manchester United Kingdom United Kingdom No longer Valid (S)-(-)-tetrahydro-2-furoic acid 433-770-5 - 2021 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (S)-(-)-tetrahydro-2-furoic acid 433-770-5 - - View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (S)-1’- (tert-butyl)-2’-oxo-1’,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxylic acid - - - View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]-bipyridine]-3-carboxylic acid - - - View substance registered dossier
Cambrex Karlskoga AB Bjorkborns Industriomrade 69185 Karlskoga Sweden Sweden Cease Manufacture (S)-2-(1-aminopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one hydrochloride 942-180-1 - 2017 View substance registered dossier
Flamma S.p.a. via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy Italy Active (S)-2-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoic acid 951-381-3 - 2021 View substance registered dossier
[Confidential] - - - (S)-2-(5-Methylheteromonocycle-2-carboxamido)-alkenoic acid - - - View substance registered dossier
- - - - (S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one 480-320-9 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one 480-320-9 - - View substance registered dossier
[Confidential] - - - (S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one 480-320-9 - - View substance registered dossier
Krka, d. d., Novo mesto Smarjeska cesta 6 SI-8501 Novo mesto Slovenia Slovenia Active (S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one 480-320-9 - - View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Active (S)-5-chloro-4-methyl-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole dihydrochloride 948-271-2 - - View substance registered dossier
- - - - (S)-7-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one glucopyranosyl ether 471-940-0 - - View substance registered dossier
MinAscent Leuna Production GmbH Am Haupttor Gebäude 4208 06237 Leuna Germany Germany Active (S)-[2-(phenylmethoxy)propylidene]hydrazinecarboxylate, tert-butyle 439-220-0 - - View substance registered dossier
- - - - (S)-[2-(phenylmethoxy)propylidene]hydrazinecarboxylate, tert-butyle 439-220-0 - - View substance registered dossier
Fine Organics Limited Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom United Kingdom No longer Valid (S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate 445-820-3 - 2021 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate 445-820-3 - - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland Active (S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate 445-820-3 - - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate 445-820-3 - - View substance registered dossier
Pliva Hrvatska doo Prilaz baruna Filipovića 25 10000 Zagreb Croatia Croatia Active (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-amine 942-077-1 - - View substance registered dossier
CU Chemie Uetikon GmbH Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany Germany Active (S)-propane-1,2-diamine bis((2S,3S)-2,3-dihydroxysuccinate) dihydrate 924-425-4 - - View substance registered dossier
Arran Chemical Company Ltd Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland Ireland Active (S)-propane-1,2-diamine bis((2S,3S)-2,3-dihydroxysuccinate) dihydrate 924-425-4 - - View substance registered dossier
Cambrex Karlskoga AB Bjorkborns Industriomrade 69185 Karlskoga Sweden Sweden Cease Manufacture (S)-tert-butyl(1-((3-fluoro-2-(phenylcarbamoyl)phenyl)amino)-1-oxobutan-2 yl)carbamate 942-159-7 - 2017 View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Active (S)-tert.-Butyl-[2-(aminoethoxy)-[1,2]oxaborolan-4-yl]acetate 942-682-0 - - View substance registered dossier
Bábolna Bioenvironmental Centre Ltd. Szállás u. 6. H-1107 Budapest Hungary Hungary Active (S)Ammonium-(2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate 926-381-1 - - View substance registered dossier
ABCR Laboratorios, S.L. Poligono Industrial de Vilapouca 36555 Forcarei Galicia Spain Spain Active (Trimethoxysilyl)methyl 2-methacrylate 454-220-0 - - View substance registered dossier
Wacker Chemie AG Hanns-Seidel-Platz 4 81737 Muenchen Germany Germany Active (Trimethoxysilyl)methyl 2-methacrylate 454-220-0 - 2016 View substance registered dossier
CAVENAGHI SPA via Varese 19 20020 lainate Italy Italy Active (xylenes and 4-ethylbenzene)sulfonic acids 701-247-3 - 2019 View substance registered dossier
STEPAN EUROPE SAS OR chemin Jongkind CS 20127 38341 VOREPPE France France Active (xylenes and 4-ethylbenzene)sulfonic acids 701-247-3 - 2018; 2021 View substance registered dossier
Experien Chemical Services (Ireland) Limited Unit 3D North Point House North Point Business Park, New Mallow Road TS23 AT2P Cork Ireland Ireland Active (xylenes and 4-ethylbenzene)sulfonic acids 701-247-3 - 2019; 2021 View substance registered dossier
Charles River Laboratories Den Bosch B.V. OR63 Hambakenwetering 7 5231DD 's-Hertogenbosch Netherlands Netherlands Active (xylenes and 4-ethylbenzene)sulfonic acids 701-247-3 - 2019 View substance registered dossier
ALCOVER QUIMICA S.L. CARRETERA MONTBLANC Km 24 43460 ALCOVER Spain Spain Active (xylenes and 4-ethylbenzene)sulfonic acids 701-247-3 - 2018 View substance registered dossier
Innospec Performance Chemicals France SAS Zone Industrielle de Han Sur Meuse BP19 55300 Saint-Mihiel France France Active (xylenes and 4-ethylbenzene)sulfonic acids 701-247-3 - 2017; 2018; 2022 View substance registered dossier
PHARMEGIC HEALTHCARE LIMITED 6th Floor, Konstitucijos av. 21A, 08130 Vilnius Lithuania Ireland Ireland Active (xylenes and 4-ethylbenzene)sulfonic acids 701-247-3 - - View substance registered dossier
Habrinol Decin Tovarni 63 407 11 Decin XXXII Decin Czech Republic Czech Republic Active (xylenes and 4-ethylbenzene)sulfonic acids 701-247-3 - 2019 View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Active (Z)-3-(chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide 953-723-7 - - View substance registered dossier
Sabinsa Europe GmbH Monzastrasse 4 63225 Langen Hessen Germany Germany Active (Z)-but-2-enedioic acid;N-[2-(dimethylamino)ethyl]-5-(dithiolan-3-yl)pentanamide 922-363-2 - - View substance registered dossier
LEVACO Chemicals GmbH CHEMPARK 51368 Leverkusen Germany Germany Active 1,1'-(dodecylimino)dipropan-2-ol + 1,1'-(tetradecylimino)dipropan-2-ol 911-174-0 - - View substance registered dossier
[Confidential] - - - 1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea) 416-600-4 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Danish competent national authority. - - Active 1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea) 416-600-4 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. - - Active 1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea) 416-600-4 - - View substance registered dossier
Sika Deutschland GmbH Kornwestheimer Str. 103 - 107 70439 Stuttgart Germany Germany Active 1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea) 416-600-4 - 2013; 2016; 2019; 2020 View substance registered dossier
SIKA France SA 101 Rue de Tolbiac B.P. 377 75626 Paris Cédex 13 France France Active 1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea) 416-600-4 - 2010; 2011; 2013; 2016; 2019; 2020 View substance registered dossier
BOSTIK S.A. 420, rue d’Estienne d’Orves 92705 Colombes Cedex France France France Active 1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea) 416-600-4 - 2020 View substance registered dossier
Sika Polyurethane Manufacturing S.R.L. Via Crosa 23/31 Sede in Cerano 28065 Cerano (NO) Italy Italy Active 1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea) 416-600-4 - 2013; 2016; 2019; 2020 View substance registered dossier
Sika Deutschland GmbH - OR Sika Manufacturing AG Kornwestheimer Str. 103-107 70439 Stuttgart Germany Germany Active 1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea) 416-600-4 - 2011; 2013; 2016; 2018; 2019; 2020 View substance registered dossier
Bostik AB Strandbadsvägen 22 251 09 Helsingborg Sweden Sweden Active 1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea) 416-600-4 - 2010; 2011; 2021 View substance registered dossier
N.P.T. S.R.L. a Socio Unico Via Guido Rossa 2 40053 Valsamoggia- Loc. Crespellano Italy Italy Active 1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea) 416-600-4 - 2020 View substance registered dossier
Nouryon Functional Chemicals B.V. Haaksbergweg 88 1101 BZ Amsterdam The Netherlands Netherlands Netherlands Active 1,1'-[propane-1,3-diylbis(oxy)]bis(2-bromo-4-tert-butylbenzene) 925-064-5 - 2019 View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 1,1'-Biphenyl, 4'-butyl-3-fluoro- 935-978-6 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 1,1'-bis(diphenylphosphino) ferrocene 430-420-3 - - View substance registered dossier
Huntsman (Europe) BV - OR2 Everslaan 45 B-3078 Everberg Belgium Belgium Active 1,1'-Methylenebis(4-isocyanatobenzene) and 1,1'-methylenebis(4-isocyanatobenzene) homopolymer and their reaction products with [(methylethylene)bis(oxy)]dipropanol and butane-1,3-diol and propane-1,2-diol 701-393-8 - 2017; 2019; 2021 View substance registered dossier
HUNTSMAN HOLLAND BV Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands Netherlands Active 1,1'-Methylenebis(4-isocyanatobenzene) and 1,1'-methylenebis(4-isocyanatobenzene) homopolymer and their reaction products with [(methylethylene)bis(oxy)]dipropanol and butane-1,3-diol and propane-1,2-diol 701-393-8 - 2011; 2012; 2013; 2015; 2019; 2021 View substance registered dossier
BASF Polyurethanes GmbH Elastogranstr. 60 49448 Lemförde Niedersachsen Germany Germany Active 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2012; 2019 View substance registered dossier
DOW DEUTSCHLAND ANLAGENGESELLSCHAFT mbH Buetzflether Sand 2 D-21683 Stade Germany Germany Active 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2022 View substance registered dossier
DOW BENELUX B.V. Postbus 48 4530 AA Terneuzen Netherlands Netherlands Active 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2013; 2014; 2016; 2019; 2022 View substance registered dossier
Covestro Deutschland AG OR US_001257 Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany Germany Active 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2012; 2017; 2019; 2021 View substance registered dossier
PLIXXENT GmbH & Co. KG Mittelkamp 112 26125 Oldenburg Germany Germany Cease Manufacture 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2022 View substance registered dossier
DOW ITALIA S.R.L. Via F. Albani 65 20148 Milano Italy Italy Active 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2019; 2022 View substance registered dossier
COVESTRO, S.L. C/. Feixa LLarga, 7 08040 Barcelona Spain Spain Active 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2019; 2021 View substance registered dossier
Covestro Deutschland AG Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany Germany Active 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2012; 2014; 2016; 2017; 2018; 2019; 2021 View substance registered dossier
BASF Espanola S.L. Calle Can Ràbia, n. 3-5 8017 Barcelona Spain Spain Active 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2012; 2019 View substance registered dossier
Huntsman International (Italy) Via Mazzini 58 21020 Ternate Italy Italy Cease Manufacture 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2021 View substance registered dossier
BASF Italia S.p.A. Via Marconato 8 20811 Cesano Maderno Italy Italy Active 1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol 701-124-4 - 2012; 2019 View substance registered dossier
HUNTSMAN HOLLAND BV Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands Netherlands Active 1,1'-methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with butane-1,3-diol, 2,2'-oxydiethanol and propane-1,2-diol 701-173-1 - 2011; 2012; 2013; 2014; 2019; 2021 View substance registered dossier
BASF Antwerpen N.V. Haven 725, Scheldelaan 600 2040 Antwerpen 4 Antwerpen Belgium Belgium Active 1,1'-Methylenebis(4-isocyanatobenzene) and oligomeric reaction products of 1,1'-methylenebis(4-isocyanatobenzene) and oxydipropanol and oligomerization reaction products of oxydipropanol 701-041-3 - 2012; 2014; 2017; 2019; 2021 View substance registered dossier
BASF Espanola S.L. Calle Can Ràbia, n. 3-5 8017 Barcelona Spain Spain Active 1,1'-Methylenebis(4-isocyanatobenzene) and oligomeric reaction products of 1,1'-methylenebis(4-isocyanatobenzene) and oxydipropanol and oligomerization reaction products of oxydipropanol 701-041-3 - 2014; 2018 View substance registered dossier
BASF Polyurethanes GmbH Elastogranstr. 60 49448 Lemförde Niedersachsen Germany Germany Active 1,1'-Methylenebis(4-isocyanatobenzene) and oligomeric reaction products of 1,1'-methylenebis(4-isocyanatobenzene) and oxydipropanol and oligomerization reaction products of oxydipropanol 701-041-3 - 2012; 2014; 2018 View substance registered dossier
BASF Italia S.p.A. Via Marconato 8 20811 Cesano Maderno Italy Italy Active 1,1'-Methylenebis(4-isocyanatobenzene) and oligomeric reaction products of 1,1'-methylenebis(4-isocyanatobenzene) and oxydipropanol and oligomerization reaction products of oxydipropanol 701-041-3 - 2014; 2018 View substance registered dossier
ARCHROMA IBÉRICA, S.L. ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain Spain Active 1,1'-{(phenylmethanediyl)bis[(3-substituted benzene-4,1-diyl)diazene-2,1-diyl{1-[3-(dimethylamino)propyl]-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridine-5,3-diyl}]}dipyridinium chloride lactate salts 700-136-7 - 2011; 2013 View substance registered dossier
Gedeon Richter Plc. Gyomroi ut 19-21 1103 Budapest Hungary Hungary Active 1,1'-{2-(2,4-difluorophenyl)-2-[(trimethylsilyl)oxy]propane-1,3-diyl}bis(1H-1,2,4-triazole) 928-141-1 - 2018; 2021 View substance registered dossier
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17, 22363 Lund Sweden Sweden Active 1,1,1"((methylsilanetriyl)tris)(oxy))tris(2-methylpropan-2-amine) - - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Belgian competent national authority. - - Active 1,1,1,2,3,3-hexafluoro-3-methoxy-2-(trifluoromethyl)propane 422-270-2 - - View substance registered dossier
INVENTEC 20 rue de Bourgogne 69800 Saint-Priest France France Active 1,1,1,2,3,3-hexafluoro-3-methoxy-2-(trifluoromethyl)propane 422-270-2 - 2021 View substance registered dossier
Microcare Europe bvba Vekestraat 29 B11 Industriezone 't Sas 1910 Kampenhout Belgium Belgium Active 1,1,1,2,3,3-hexafluoro-3-methoxy-2-(trifluoromethyl)propane 422-270-2 - - View substance registered dossier
Charles River Laboratories Den Bosch B.V. OR65 Hambakenwetering 7 5231 DD 's-Hertogenbosch Netherlands Netherlands Active 1,1,1,2,3,3-hexafluoro-3-methoxy-2-(trifluoromethyl)propane 422-270-2 - 2012 View substance registered dossier
3M Belgium BVBA/SPRL Hermeslaan 7 1831 Diegem Belgium Belgium Active 1,1,1,2,3,3-hexafluoro-3-methoxy-2-(trifluoromethyl)propane 422-270-2 - 2011; 2015; 2017; 2019; 2020; 2022 View substance registered dossier
3M Belgium BVBA/SPRL Hermeslaan 7 1831 Diegem Belgium Belgium Active 1,1,1,2,3,3-hexafluoro-4-(1,1,2,3,3,3-hexafluoropropoxy)pentane 484-290-8 - 2011 View substance registered dossier
Merck Performance Materials GmbH Rheingaustrasse 190-196 65203 Wiesbaden Germany Germany Cease Manufacture 1,1,1-tris(phenyl-4'-(6''-diazo-5'',6''-dihydro-5''-oxo-naphthalene-1''-sulfonato)ethane;reaction mass of: 1,1,1-tris(phenyl-4'-(3''-diazo-3'',4''-dihydro-4''-oxo-naphthalene-1''-sulfonato)ethane;reaction product of 1,1,1-tris(p-hydroxyphenyl)ethane with 6-diazo-5,6-dihydro-5-oxo-1-naphthylsulfonylchloride and 3-diazo-3,4-dihydro-4-oxo-1-naphthylsulfonylchloride (1:2);reaction product of 1,1,1-tris(p-hydroxyphenyl)ethane with 6-diazo-5,6-dihydro-5-oxo-1-naphthylsulfonylchloride and 3-diazo-3,4-dihydro-4-oxo-1-naphthylsulfonylchloride (2:1) 422-760-6 - 2019 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. - - Active 1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(2-hydroxyethyl)-1-butanesulfonamide 454-680-2 - - View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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